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    Leucine-rich repeat protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822474, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Leucine-rich repeat protein kinase family protein
    Primary source
    TAIR:AT3G28450
    Locus tag
    AT3G28450
    See related
    Araport:AT3G28450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BAK1-interacting receptor-like kinase 2; BIR2
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (10667135..10669428)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Putative membrane lipoprotein Neighboring gene CLEC16A-like protein Neighboring gene CLAVATA3/ESR-RELATED 25 Neighboring gene methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The BIR2/BIR3-Associated Phospholipase Dγ1 Negatively Regulates Plant Immunity. Schlöffel MA, et al. Plant Physiol, 2020 May. PMID 32152212, Free PMC Article
    2. Structure of the pseudokinase domain of BIR2, a regulator of BAK1-mediated immune signaling in Arabidopsis. Blaum BS, et al. J Struct Biol, 2014 Apr. PMID 24556575
    3. The leucine-rich repeat receptor kinase BIR2 is a negative regulator of BAK1 in plant immunity. Halter T, et al. Curr Biol, 2014 Jan 20. PMID 24388849
    4. Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Popescu SC, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360592, Free PMC Article
    5. An extracellular network of Arabidopsis leucine-rich repeat receptor kinases. Smakowska-Luzan E, et al. Nature, 2018 Jan 18. PMID 29320478, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The BIR2/BIR3-Associated Phospholipase Dgamma1 Negatively Regulates Plant Immunity.
      Title: The BIR2/BIR3-Associated Phospholipase Dγ1 Negatively Regulates Plant Immunity.
    2. Crystal structure of the Arabidopsis BIR2 cytosolic domain
      Title: Structure of the pseudokinase domain of BIR2, a regulator of BAK1-mediated immune signaling in Arabidopsis.
    3. results provide evidence for a new regulatory mechanism for innate immune receptors with BIR2 acting as a negative regulator of PAMP-triggered immunity by limiting BAK1-receptor complex formation in the absence of ligands. [BIR2]
      Title: The leucine-rich repeat receptor kinase BIR2 is a negative regulator of BAK1 in plant immunity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_113765.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucine-rich repeat protein kinase family protein
    NP_189486.1
    • Leucine-rich repeat protein kinase family protein; FUNCTIONS IN: protein serine/threonine kinase activity, kinase activity, ATP binding; INVOLVED IN: transmembrane receptor protein tyrosine kinase signaling pathway, protein amino acid phosphorylation; LOCATED IN: chloroplast, plasma membrane, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT1G27190.1); Has 101664 Blast hits to 59951 proteins in 2302 species: Archae - 40; Bacteria - 6408; Metazoa - 16028; Fungi - 2446; Plants - 69126; Viruses - 161; Other Eukaryotes - 7455 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      10667135..10669428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113765.3 → NP_189486.1  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189486.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LSI9
      UniProtKB/TrEMBL
      A0A178VC42, A0A5S9XGM0
      Conserved Domains (6) summary
      cd00116
      Location:83 → 190
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:104 → 128
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00069
      Location:319 → 574
      Pkinase; Protein kinase domain
      pfam08263
      Location:30 → 73
      LRRNT_2; Leucine rich repeat N-terminal domain
      pfam13855
      Location:103 → 163
      LRR_8; Leucine rich repeat
      cl21453
      Location:313 → 578
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LSI9.1

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