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    MSD1 manganese superoxide dismutase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820263, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MSD1
    Official Full Name
    manganese superoxide dismutase 1
    Primary source
    TAIR:AT3G10920
    Locus tag
    AT3G10920
    See related
    Araport:AT3G10920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS MANGANESE SUPEROXIDE DISMUTASE 1; ATMSD1; AtSOD1; manganese superoxide dismutase 1; MANGANESE SUPEROXIDE DISMUTASE 1; MATERNAL EFFECT EMBRYO ARREST 33; MEE33; superoxide dismutase 1
    Summary
    manganese superoxide dismutase (MSD1)
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    Genomic context

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    See MSD1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (3417940..3419892)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene Reticulon family protein Neighboring gene uncharacterized protein Neighboring gene dual specificity protein phosphatase (DsPTP1) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An anchoring complex recruits katanin for microtubule severing at the plant cortical nucleation sites. Yagi N, et al. Nat Commun, 2021 Jun 17. PMID 34140499, Free PMC Article
    2. Expression, purification and crystallization of MnSOD from Arabidopsis thaliana. Marques AT, et al. Acta Crystallogr F Struct Biol Commun, 2014 May. PMID 24817734, Free PMC Article
    3. oiwa, a female gametophytic mutant impaired in a mitochondrial manganese-superoxide dismutase, reveals crucial roles for reactive oxygen species during embryo sac development and fertilization in Arabidopsis. Martin MV, et al. Plant Cell, 2013 May. PMID 23653473, Free PMC Article
    4. Decrease in manganese superoxide dismutase leads to reduced root growth and affects tricarboxylic acid cycle flux and mitochondrial redox homeostasis. Morgan MJ, et al. Plant Physiol, 2008 May. PMID 18337490, Free PMC Article
    5. Differential inhibition of Arabidopsis superoxide dismutases by peroxynitrite-mediated tyrosine nitration. Holzmeister C, et al. J Exp Bot, 2015 Feb. PMID 25428993, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An anchoring complex recruits katanin for microtubule severing at the plant cortical nucleation sites.
      Title: An anchoring complex recruits katanin for microtubule severing at the plant cortical nucleation sites.
    2. Peroxynitrite inhibited mitochondrial manganese superoxide dismutase (SOD1; MSD1), peroxisomal copper/zinc SOD3 (CSD3), and chloroplastic iron SOD3 (FSD3), but no other SODs. MSD1 was inhibited by up to 90% but CSD3 and FSD3 only by a maximum of 30%.
      Title: Differential inhibition of Arabidopsis superoxide dismutases by peroxynitrite-mediated tyrosine nitration.
    3. Manganese superoxide dismutase from Arabidopsis was expressed, purified and crystallized.
      Title: Expression, purification and crystallization of MnSOD from Arabidopsis thaliana.
    4. Data indicate that Mn-superoxide dismutase MSD1 activity seems critical for maintaining reactive oxygen species (ROS) localization and important for embryo sac patterning.
      Title: oiwa, a female gametophytic mutant impaired in a mitochondrial manganese-superoxide dismutase, reveals crucial roles for reactive oxygen species during embryo sac development and fertilization in Arabidopsis.
    5. Reduced MnSOD affects mitochondrial redox balance and plant growth.
      Title: Decrease in manganese superoxide dismutase leads to reduced root growth and affects tricarboxylic acid cycle flux and mitochondrial redox homeostasis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_001035593.2
    NM_111929.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding HDA PubMed 
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables superoxide dismutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables superoxide dismutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within removal of superoxide radicals IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    manganese superoxide dismutase 1
    NP_001030670.1
    • manganese superoxide dismutase 1 (MSD1); FUNCTIONS IN: superoxide dismutase activity, copper ion binding, metal ion binding; INVOLVED IN: response to zinc ion, response to salt stress, defense response to bacterium, removal of superoxide radicals, embryo development ending in seed dormancy; LOCATED IN: mitochondrion; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Iron/manganese superoxide dismutase family protein (TAIR:AT3G56350.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_187703.1
    • manganese superoxide dismutase 1 (MSD1); FUNCTIONS IN: superoxide dismutase activity, copper ion binding, metal ion binding; INVOLVED IN: response to zinc ion, response to salt stress, defense response to bacterium, removal of superoxide radicals, embryo development ending in seed dormancy; LOCATED IN: mitochondrion; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Iron/manganese superoxide dismutase family protein (TAIR:AT3G56350.1); Has 11404 Blast hits to 11403 proteins in 3385 species: Archae - 194; Bacteria - 8096; Metazoa - 447; Fungi - 710; Plants - 427; Viruses - 1; Other Eukaryotes - 1529 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3417940..3419892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111929.4 → NP_187703.1  manganese superoxide dismutase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187703.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81235, Q8LEP0, Q9SRK3
      UniProtKB/TrEMBL
      A0A178VDR9, A0A5S9XB82
      Conserved Domains (3) summary
      PLN02471
      Location:1 → 231
      PLN02471; superoxide dismutase [Mn]
      pfam00081
      Location:30 → 111
      Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
      pfam02777
      Location:121 → 224
      Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain

    2. NM_001035593.2 → NP_001030670.1  manganese superoxide dismutase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030670.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VDR9, A0A5S9XB82, F4J504
      Conserved Domains (3) summary
      PLN02471
      Location:1 → 230
      PLN02471; superoxide dismutase [Mn]
      pfam00081
      Location:30 → 111
      Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
      pfam02777
      Location:121 → 223
      Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O81235.2

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