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    ANL2 Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828022, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ANL2
    Official Full Name
    Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein
    Primary source
    TAIR:AT4G00730
    Locus tag
    AT4G00730
    See related
    Araport:AT4G00730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AHDP; ANTHOCYANINLESS 2; ARABIDOPSIS THALIANA HOMEODOMAIN PROTEIN; F6N23.10; F6N23_10; HOMEODOMAIN PROTEIN AHDP
    Summary
    Encodes a homeodomain protein of the HD-GLABRA2 group. Involved in the accumulation of anthocyanin and in root development
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    Genomic context

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    See ANL2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (299261..304612, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene BR-signaling kinase 3 Neighboring gene shaggy-like protein kinase 32 Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenotypic screening of Arabidopsis T-DNA insertion lines for cell wall mechanical properties revealed ANTHOCYANINLESS2, a cell wall-related gene. Mabuchi A, et al. J Plant Physiol, 2016 Feb 1. PMID 26720211
    2. Characterization of root cells of anl2 mutant in Arabidopsis thaliana. Kubo H, et al. Plant Sci, 2011 May. PMID 21421418
    3. ANTHOCYANINLESS2, a homeobox gene affecting anthocyanin distribution and root development in Arabidopsis. Kubo H, et al. Plant Cell, 1999 Jul. PMID 10402424, Free PMC Article
    4. Pleiotropic phenotypes of the sticky peel mutant provide new insight into the role of CUTIN DEFICIENT2 in epidermal cell function in tomato. Nadakuduti SS, et al. Plant Physiol, 2012 Jul. PMID 22623518, Free PMC Article
    5. AIL and HDG proteins act antagonistically to control cell proliferation. Horstman A, et al. Development, 2015 Feb 1. PMID 25564655

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANTHOCYANINLESS2 (ANL2), a gene involved in the regulation of cell wall mechanical properties, was identified.
      Title: Phenotypic screening of Arabidopsis T-DNA insertion lines for cell wall mechanical properties revealed ANTHOCYANINLESS2, a cell wall-related gene.
    2. In plants with an ANL2 gene mutation, extra (intervening) cells develop from epidermal cells but become cortical in nature, and expression of some epidermis-specific genes is abnormal.
      Title: Characterization of root cells of anl2 mutant in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    NM_001125435.1
    NM_116298.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anthocyanin accumulation in tissues in response to UV light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cutin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein
    NP_001118907.1
    • ANTHOCYANINLESS 2 (ANL2); FUNCTIONS IN: transcription regulator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: root development, anthocyanin accumulation in tissues in response to UV light; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeodomain GLABROUS 1 (TAIR:AT3G61150.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_567183.2
    • ANTHOCYANINLESS 2 (ANL2); FUNCTIONS IN: transcription regulator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: root development, anthocyanin accumulation in tissues in response to UV light; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeobox, conserved site (InterPro:IPR017970), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeodomain GLABROUS 1 (TAIR:AT3G61150.1); Has 12660 Blast hits to 12608 proteins in 595 species: Archae - 0; Bacteria - 0; Metazoa - 9962; Fungi - 223; Plants - 2228; Viruses - 1; Other Eukaryotes - 246 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      299261..304612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116298.4 → NP_567183.2  Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567183.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65281, P93041, Q0WV12, Q9SWZ6
      UniProtKB/TrEMBL
      A0A5S9XPH6
      Conserved Domains (3) summary
      cd08875
      Location:319 → 542
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      COG5576
      Location:99 → 209
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:137 → 190
      Homeobox; Homeobox domain

    2. NM_001125435.1 → NP_001118907.1  Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3H591
      Conserved Domains (3) summary
      cd08875
      Location:319 → 542
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      COG5576
      Location:99 → 209
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:137 → 190
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WV12.1

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