BSK3 BR-signaling kinase 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BSK3
Official Full Name: BR-signaling kinase 3
Primary source: TAIR:AT4G00710
Locus tag: AT4G00710
See related: Araport:AT4G00710
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BR-signaling kinase 3; brassinosteroid-signaling kinase 3; F6N23.9; F6N23_9
Summary: Encodes BR-signaling kinase 3 (BSK3), one of the three homologous BR-signaling kinases (BSK1, AT4G35230; BSK2, AT5G46570; BSK3, AT4G00710). Mediates signal transduction from receptor kinase BRI1 by functioning as the substrate of BRI1. Plasma membrane localized.
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Genomic context

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See BSK3 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 11

Sequence:: Chromosome: 4; NC_003075.7 (289779..293492)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BSK3 modulates root elongation under mild nitrogen deficiency. In particular, a proline to leucine substitution in the predicted kinase domain of BSK3 enhances brassinosteroid sensitivity and signaling to increase the extent of root elongation.
Title: Natural variation of BSK3 tunes brassinosteroid signaling to regulate root foraging under low nitrogen.
we find that BSK3 upregulates BSU1 transcript and protein levels to activate BR signaling. BSK3 is broadly expressed and plays an important role in BR-mediated root growth, shoot growth, and organ separation. Together, our findings suggest that BSK3 may function as a scaffold protein to regulate BR signaling. The results of our studies provide new insights into early BR signaling mechanisms.
Title: BRASSINOSTEROID-SIGNALING KINASE 3, a plasma membrane-associated scaffold protein involved in early brassinosteroid signaling.
BSK3 interacts with multiple receptor-like kinases in Arabidopsis.
Title: A brassinosteroid-signaling kinase interacts with multiple receptor-like kinases in Arabidopsis.
3 homologous brassinosteroid (BR)-signaling kinases (BSK1, BSK2 & BSK3)were identified; the BSKs are phosphorylated by BRI1; results demonstrate that BSKs are the substrates of BRI1 kinase that activate downstream BR signal transduction. [BSK3]
Title: BSKs mediate signal transduction from the receptor kinase BRI1 in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001340265.1

Supported by ESTs:

NM_116296.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brassinosteroid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brassinosteroid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: BR-signaling kinase 3

NP_191980.2

BR-signaling kinase 3 (BSK3); FUNCTIONS IN: binding, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: brassinosteroid mediated signaling pathway, N-terminal protein myristoylation; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Protein kinase, catalytic domain (InterPro:IPR000719), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase protein with tetratricopeptide repeat domain (TAIR:AT1G01740.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

289779..293492

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116296.4 → NP_191980.2 BR-signaling kinase 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191980.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O65280, Q8W4L3

UniProtKB/TrEMBL

A0A178V3B2, A0A7G2EV77

Conserved Domains (2) summary

sd00006
Location:385 → 409

TPR; TPR repeat [structural motif]

cl21453
Location:72 → 312

PKc_like; Protein Kinases, catalytic domain
NM_001340265.1 → NP_001329175.1 BR-signaling kinase 3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O65280, Q8W4L3

UniProtKB/TrEMBL

A0A178V3B2, A0A7G2EV77

Conserved Domains (2) summary

sd00006
Location:385 → 409

TPR; TPR repeat [structural motif]

cl21453
Location:72 → 312

PKc_like; Protein Kinases, catalytic domain