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    PFA-DSP4 Phosphotyrosine protein phosphatases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825706, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PFA-DSP4
    Official Full Name
    Phosphotyrosine protein phosphatases superfamily protein
    Primary source
    TAIR:AT4G03960
    Locus tag
    AT4G03960
    See related
    Araport:AT4G03960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtPFA-DSP4; plant and fungi atypical dual-specificity phosphatase 4; T24M8.4; T24M8_4
    Summary
    Encodes an atypical dual-specificity phosphatase involved in the negative regulation of defense response to a bacterial pathogen, P. syringae pv. tomato.
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    Genomic context

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    See PFA-DSP4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (1887462..1889255)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene Nucleotide/sugar transporter family protein Neighboring gene RING/U-box superfamily protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two homologous putative protein tyrosine phosphatases, OsPFA-DSP2 and AtPFA-DSP4, negatively regulate the pathogen response in transgenic plants. He H, et al. PLoS One, 2012. PMID 22514699, Free PMC Article
    2. Arabidopsis PFA-DSP-Type Phosphohydrolases Target Specific Inositol Pyrophosphate Messengers. Gaugler P, et al. Biochemistry, 2022 Jun 21. PMID 35640071, Free PMC Article
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_116634.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Phosphotyrosine protein phosphatases superfamily protein
    NP_567261.1
    • Phosphotyrosine protein phosphatases superfamily protein; FUNCTIONS IN: phosphatase activity, protein tyrosine phosphatase activity, phosphoprotein phosphatase activity; INVOLVED IN: dephosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Protein-tyrosine phosphatase, dual specificity phosphatase, eukaryotic (InterPro:IPR020428), Protein-tyrosine phosphatase, SIW14-like (InterPro:IPR004861); BEST Arabidopsis thaliana protein match is: Phosphotyrosine protein phosphatases superfamily protein (TAIR:AT1G05000.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      1887462..1889255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116634.4 → NP_567261.1  Phosphotyrosine protein phosphatases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567261.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81513, Q940L5
      UniProtKB/TrEMBL
      A0A654FM04
      Conserved Domains (1) summary
      cd14528
      Location:28 → 175
      PFA-DSP_Siw14; atypical dual specificity phosphatases similar to yeast Siw14
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q940L5.1

    Gene LinkOut

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