CPK4 calcium-dependent protein kinase 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CPK4
Official Full Name: calcium-dependent protein kinase 4
Primary source: TAIR:AT4G09570
Locus tag: AT4G09570
See related: Araport:AT4G09570
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCPK4; calcium-dependent protein kinase 4; T25P22.10; T25P22_10
Summary: Encodes a member of Calcium Dependent Protein Kinase (CDPK) gene family.Positive regulator of ABA signaling. Phosphorylates ABA responsive transcription factors ABF1 and ABF4.
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Genomic context

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See CPK4 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 7

Sequence:: Chromosome: 4; NC_003075.7 (6049441..6052380)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Substrate profiling of the Arabidopsis Ca[2+]-dependent protein kinase AtCPK4 and its Ricinus communis ortholog RcCDPK1.
Title: Substrate profiling of the Arabidopsis Ca(2+)-dependent protein kinase AtCPK4 and its Ricinus communis ortholog RcCDPK1.
Calcium-dependent ABA signaling functions in stomatal immunity by regulating rapid SA responses in guard cells.
Title: Calcium-dependent ABA signaling functions in stomatal immunity by regulating rapid SA responses in guard cells.
CPK4 binds to and phosphorylates RopGEF1 and promotes the degradation of RopGEF1
Title: Abscisic acid-induced degradation of Arabidopsis guanine nucleotide exchange factor requires calcium-dependent protein kinases.
This study discovered that a key Abscisic acid (ABA) signaling component calcium-dependent protein kinase 4 (CPK4) can interact with AtIpk2 beta under ABA treated conditions through affinity purification and mass spectrometry detection.
Title: Arabidopsis inositol polyphosphate kinase AtIpk2β is phosphorylated by CPK4 and positively modulates ABA signaling.
Two abscisic acid (ABA)-activated calcium-dependent protein kinases, CPK4 and CPK11, phosphorylate the C-terminus of ACS6 and increase the stability of ACS6 in ethylene biosynthesis.
Title: Abscisic acid inhibits root growth in Arabidopsis through ethylene biosynthesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_117025.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: calcium-dependent protein kinase 4

NP_192695.1

calcium-dependent protein kinase 4 (CPK4); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Serine/threonine-protein kinase domain (InterPro:IPR002290), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), EF-HAND 2 (InterPro:IPR018249), Calcium-dependent protein kinase (InterPro:IPR020642), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: calcium-dependent protein kinase 2 (TAIR:AT1G35670.1); Has 132709 Blast hits to 123975 proteins in 4221 species: Archae - 161; Bacteria - 14258; Metazoa - 49454; Fungi - 17991; Plants - 27137; Viruses - 592; Other Eukaryotes - 23116 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

6049441..6052380

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117025.6 → NP_192695.1 calcium-dependent protein kinase 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192695.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q38869

UniProtKB/TrEMBL

A0A178UX60, A0A178W2R7, A0A5S9XQR7

Conserved Domains (2) summary

PTZ00184
Location:319 → 461

PTZ00184; calmodulin; Provisional

cd05117
Location:24 → 282

STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases