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    DTX35 detoxifying efflux carrier 35 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828669, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DTX35
    Official Full Name
    detoxifying efflux carrier 35
    Primary source
    TAIR:AT4G25640
    Locus tag
    AT4G25640
    See related
    Araport:AT4G25640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATDTX35; detoxifying efflux carrier 35; FFT; FLOWER FLAVONOID TRANSPORTER; L73G19.20; L73G19_20
    Summary
    Encodes a multidrug and toxin efflux family transporter. Involved in flavonoid metabolism, affecting Root growth, seed development and germination, and pollen development, release and viability.
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    Genomic context

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    See DTX35 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Sequence:
    Chromosome: 4; NC_003075.7 (13076444..13079256, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene C2H2-like zinc finger protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene fibrillarin 2 Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene ACD1-like protein Neighboring gene PPPDE putative thiol peptidase family protein Neighboring gene stress response NST1-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis pab1, a mutant with reduced anthocyanins in immature seeds from banyuls, harbors a mutation in the MATE transporter FFT. Kitamura S, et al. Plant Mol Biol, 2016 Jan. PMID 26608698
    2. An Arabidopsis flavonoid transporter is required for anther dehiscence and pollen development. Thompson EP, et al. J Exp Bot, 2010. PMID 19995827, Free PMC Article
    3. Two tonoplast MATE proteins function as turgor-regulating chloride channels in Arabidopsis. Zhang H, et al. Proc Natl Acad Sci U S A, 2017 Mar 7. PMID 28202726, Free PMC Article
    4. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The tonoplast proteins DTX33 and DTX35 function as turgor-regulating chloride channels in Arabidopsis.
      Title: Two tonoplast MATE proteins function as turgor-regulating chloride channels in Arabidopsis.
    2. FFT acts at the vacuolar membrane in anthocyanin accumulation in the Arabidopsis seed coat.
      Title: Arabidopsis pab1, a mutant with reduced anthocyanins in immature seeds from banyuls, harbors a mutation in the MATE transporter FFT.
    3. AtDTX35, a multidrug and toxin efflux family transporter, is required for anther dehiscence and pollen development. [AtDTX35]
      Title: An Arabidopsis flavonoid transporter is required for anther dehiscence and pollen development.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001341758.1
    NM_118696.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anther dehiscence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flavonoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flavonoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    detoxifying efflux carrier 35
    NP_001190838.1
    • detoxifying efflux carrier 35 (DTX35); FUNCTIONS IN: antiporter activity, drug transmembrane transporter activity; INVOLVED IN: anther dehiscence, flavonoid metabolic process, pollen development; LOCATED IN: membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Multi antimicrobial extrusion protein MatE (InterPro:IPR002528); BEST Arabidopsis thaliana protein match is: MATE efflux family protein (TAIR:AT4G00350.1).
    NP_194294.2
    • detoxifying efflux carrier 35 (DTX35); FUNCTIONS IN: antiporter activity, drug transmembrane transporter activity; INVOLVED IN: anther dehiscence, flavonoid metabolic process, pollen development; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Multi antimicrobial extrusion protein MatE (InterPro:IPR002528); BEST Arabidopsis thaliana protein match is: MATE efflux family protein (TAIR:AT4G00350.1); Has 11724 Blast hits to 11622 proteins in 2105 species: Archae - 230; Bacteria - 8860; Metazoa - 143; Fungi - 322; Plants - 1354; Viruses - 0; Other Eukaryotes - 815 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      13076444..13079256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203909.1 → NP_001190838.1  detoxifying efflux carrier 35 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190838.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V331, A0A5S9XVS3, F4JTB2
      Conserved Domains (2) summary
      cd13132
      Location:34 → 468
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
      TIGR00797
      Location:44 → 382
      matE; putative efflux protein, MATE family

    2. NM_118696.5 → NP_194294.2  detoxifying efflux carrier 35 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194294.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JTB3, Q0WWD0, Q9SZZ2
      UniProtKB/TrEMBL
      A0A178V331, A0A5S9XVS3
      Conserved Domains (2) summary
      cd13132
      Location:34 → 468
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
      TIGR00797
      Location:44 → 382
      matE; putative efflux protein, MATE family

    3. NM_001341758.1 → NP_001329321.1  detoxifying efflux carrier 35 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V331, A0A1P8B7C3, A0A5S9XVS3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JTB3.1

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