U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FAD6 fatty acid desaturase 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829220, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FAD6
    Official Full Name
    fatty acid desaturase 6
    Primary source
    TAIR:AT4G30950
    Locus tag
    AT4G30950
    See related
    Araport:AT4G30950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CHLOROPLAST PRECURSOR; F6I18.140; F6I18_140; FADC; fatty acid desaturase 6; FATTY ACID DESATURASE C; OMEGA-6 FATTY ACID DESATURASE; SFD4; STEAROYL DESATURASE DEFICIENCY 4
    Summary
    Chloroplastic enzyme responsible for the synthesis of 16:2 and 18:2 fatty acids from galactolipids, sulpholipids and phosphatidylglycerol. Uses ferredoxin as electron donor. Gene mutation resulted in reduced level of unsaturated fatty acids leading to susceptibility to photoinhibition.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FAD6 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (15056975..15059846, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene WRKY DNA-binding protein 32 Neighboring gene BTB/POZ domain with WD40/YVTN repeat-like protein Neighboring gene ncRNA Neighboring gene SOS3-interacting protein 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Fatty acid desaturase-6 (Fad6) is required for salt tolerance in Arabidopsis thaliana. Zhang JT, et al. Biochem Biophys Res Commun, 2009 Dec 18. PMID 19799856
    2. Arabidopsis sfd mutants affect plastidic lipid composition and suppress dwarfing, cell death, and the enhanced disease resistance phenotypes resulting from the deficiency of a fatty acid desaturase. Nandi A, et al. Plant Cell, 2003 Oct. PMID 14507997, Free PMC Article
    3. Identification of a gene that complements an Arabidopsis mutant deficient in chloroplast omega 6 desaturase activity. Falcone DL, et al. Plant Physiol, 1994 Dec. PMID 7846158, Free PMC Article
    4. Genetic analysis of Arabidopsis mutants impaired in plastid lipid import reveals a role of membrane lipids in chloroplast division. Fan J, et al. Plant Signal Behav, 2011 Mar. PMID 21358271, Free PMC Article
    5. Photoinhibition in mutants of Arabidopsis deficient in thylakoid unsaturation. Vijayan P, et al. Plant Physiol, 2002 Jun. PMID 12068126, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The tgd1-1 fad6 and tgd4-3 fad6 double mutants were deficient in polyunsaturated fatty acids in chloroplast membrane lipids, and severely compromised in the biogenesis of photosynthetic membrane systems.
      Title: Genetic analysis of Arabidopsis mutants impaired in plastid lipid import reveals a role of membrane lipids in chloroplast division.
    2. All these results suggest that Fad6 is required for salt resistance in Arabidopsis.
      Title: Fatty acid desaturase-6 (Fad6) is required for salt tolerance in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_119243.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables omega-6 fatty acid desaturase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within photoinhibition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    fatty acid desaturase 6
    NP_194824.1
    • fatty acid desaturase 6 (FAD6); FUNCTIONS IN: omega-6 fatty acid desaturase activity; INVOLVED IN: photoinhibition, fatty acid biosynthetic process; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fatty acid desaturase, type 1 (InterPro:IPR005804); BEST Arabidopsis thaliana protein match is: fatty acid desaturase 8 (TAIR:AT5G05580.1); Has 3227 Blast hits to 3218 proteins in 733 species: Archae - 0; Bacteria - 1371; Metazoa - 67; Fungi - 380; Plants - 896; Viruses - 0; Other Eukaryotes - 513 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15056975..15059846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119243.4 → NP_194824.1  fatty acid desaturase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194824.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46312, Q9M094
      UniProtKB/TrEMBL
      A0A178V0M7, A0A5S9XXF6
      Conserved Domains (1) summary
      PLN02598
      Location:1 → 447
      PLN02598; omega-6 fatty acid desaturase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46312.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools