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    APX6 ascorbate peroxidase 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829366, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APX6
    Official Full Name
    ascorbate peroxidase 6
    Primary source
    TAIR:AT4G32320
    Locus tag
    AT4G32320
    See related
    Araport:AT4G32320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ascorbate peroxidase 6; F10M6.50; F10M6_50
    Summary
    Encodes a cytosolic ascorbate peroxidase APX6. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms.
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    Genomic context

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    See APX6 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (15602721..15605400)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase Neighboring gene S-domain-2 5 Neighboring gene TPX2 (targeting protein for Xklp2) protein family Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ASCORBATE PEROXIDASE6 delays the onset of age-dependent leaf senescence. Chen C, et al. Plant Physiol, 2021 Mar 15. PMID 33580795, Free PMC Article
    2. New cross talk between ROS, ABA and auxin controlling seed maturation and germination unraveled in APX6 deficient Arabidopsis seeds. Chen C, et al. Plant Signal Behav, 2014. PMID 25482750, Free PMC Article
    3. ASCORBATE PEROXIDASE6 protects Arabidopsis desiccating and germinating seeds from stress and mediates cross talk between reactive oxygen species, abscisic acid, and auxin. Chen C, et al. Plant Physiol, 2014 Sep. PMID 25049361, Free PMC Article
    4. Heat stress- and heat shock transcription factor-dependent expression and activity of ascorbate peroxidase in Arabidopsis. Panchuk II, et al. Plant Physiol, 2002 Jun. PMID 12068123, Free PMC Article
    5. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ASCORBATE PEROXIDASE6 delays the onset of age-dependent leaf senescence.
      Title: ASCORBATE PEROXIDASE6 delays the onset of age-dependent leaf senescence.
    2. role in protecting mature desiccating and germinating seeds from excessive oxidative damage
      Title: ASCORBATE PEROXIDASE6 protects Arabidopsis desiccating and germinating seeds from stress and mediates cross talk between reactive oxygen species, abscisic acid, and auxin.
    3. A role of APX6 in the regulation of the crosstalk between auxin, abscissic acid and reactive oxygen species, is reported.
      Title: New cross talk between ROS, ABA and auxin controlling seed maturation and germination unraveled in APX6 deficient Arabidopsis seeds.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119384.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-ascorbate peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ascorbate peroxidase 6
    NP_194958.2
    • ascorbate peroxidase 6 (APX6); FUNCTIONS IN: L-ascorbate peroxidase activity, peroxidase activity, heme binding; INVOLVED IN: response to oxidative stress, oxidation reduction; LOCATED IN: cytosol; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Plant ascorbate peroxidase (InterPro:IPR002207), Peroxidases heam-ligand binding site (InterPro:IPR019793), Haem peroxidase, plant/fungal/bacterial (InterPro:IPR002016), Peroxidase, active site (InterPro:IPR019794); BEST Arabidopsis thaliana protein match is: ascorbate peroxidase 2 (TAIR:AT3G09640.2); Has 8064 Blast hits to 8032 proteins in 1269 species: Archae - 53; Bacteria - 2233; Metazoa - 2; Fungi - 806; Plants - 4037; Viruses - 0; Other Eukaryotes - 933 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15602721..15605400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119384.4 → NP_194958.2  ascorbate peroxidase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194958.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49360, Q8GY91
      UniProtKB/TrEMBL
      A0A178V282, A0A5S9XXV8
      Conserved Domains (1) summary
      cd00314
      Location:96 → 321
      plant_peroxidase_like; Heme-dependent peroxidases similar to plant peroxidases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GY91.1

    Gene LinkOut

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