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    Hacd4 3-hydroxyacyl-CoA dehydratase 4 [ Mus musculus (house mouse) ]

    Gene ID: 66775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hacd4provided by MGI
    Official Full Name
    3-hydroxyacyl-CoA dehydratase 4provided by MGI
    Primary source
    MGI:MGI:1914025
    See related
    Ensembl:ENSMUSG00000028497 AllianceGenome:MGI:1914025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hcad4; Ptplad2; 4933428I03Rik
    Summary
    Predicted to enable enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; heart valve; and retina. Orthologous to human HACD4 (3-hydroxyacyl-CoA dehydratase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.2), genital fat pad adult (RPKM 2.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hacd4 in Genome Data Viewer
    Location:
    4 C4; 4 41.73 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (88325924..88357175, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (88407687..88438936, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 Neighboring gene predicted gene, 34232 Neighboring gene STARR-positive B cell enhancer mm9_chr4:87680226-87680527 Neighboring gene STARR-positive B cell enhancer mm9_chr4:87681371-87681672 Neighboring gene STARR-seq mESC enhancer starr_10719 Neighboring gene STARR-positive B cell enhancer ABC_E8809 Neighboring gene STARR-seq mESC enhancer starr_10720 Neighboring gene focadhesin Neighboring gene microRNA 491 Neighboring gene STARR-seq mESC enhancer starr_10721 Neighboring gene STARR-seq mESC enhancer starr_10722 Neighboring gene STARR-seq mESC enhancer starr_10723 Neighboring gene STARR-seq mESC enhancer starr_10724 Neighboring gene interferon beta 1, fibroblast Neighboring gene interferon alpha 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth. Blondelle J, et al. J Mol Cell Biol, 2015 Oct. PMID 26160855, Free PMC Article
    2. Endothelial Cyp26b1 restrains murine heart valve growth during development. Ahuja N, et al. Dev Biol, 2022 Jun. PMID 35364055
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4
    Names
    protein tyrosine phosphatase-like A domain containing 2
    protein tyrosine phosphatase-like protein PTPLAD2
    protein-tyrosine phosphatase-like A domain-containing protein 2
    very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 4
    NP_001364027.1
    NP_001364028.1
    NP_001364029.1
    NP_080036.1
    XP_006538253.1
    XP_006538255.1
    XP_006538256.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377098.1 → NP_001364027.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL772316
      UniProtKB/Swiss-Prot
      A2AKM1, A2AKM2, Q8BG85, Q9CPS2
      UniProtKB/TrEMBL
      F7CPS1
      Conserved Domains (1) summary
      pfam04387
      Location:65 → 223
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    2. NM_001377099.1 → NP_001364028.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
      Source sequence(s)
      AL772316
      UniProtKB/Swiss-Prot
      A2AKM1, A2AKM2, Q8BG85, Q9CPS2
      UniProtKB/TrEMBL
      F7CPS1
      Conserved Domains (1) summary
      pfam04387
      Location:65 → 223
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    3. NM_001377100.1 → NP_001364029.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL772316
      Conserved Domains (1) summary
      pfam04387
      Location:16 → 174
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    4. NM_025760.5 → NP_080036.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform a

      See identical proteins and their annotated locations for NP_080036.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
      Source sequence(s)
      AL772316
      Consensus CDS
      CCDS18317.1
      UniProtKB/Swiss-Prot
      A2AKM1, A2AKM2, Q8BG85, Q9CPS2
      UniProtKB/TrEMBL
      F7CPS1
      Related
      ENSMUSP00000030221.3, ENSMUST00000030221.3
      Conserved Domains (1) summary
      pfam04387
      Location:65 → 223
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      88325924..88357175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538193.4 → XP_006538256.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform X3

      UniProtKB/TrEMBL
      F7CPS1
      Conserved Domains (1) summary
      pfam04387
      Location:65 → 205
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    2. XM_006538190.4 → XP_006538253.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform X1

      See identical proteins and their annotated locations for XP_006538253.1

      UniProtKB/Swiss-Prot
      A2AKM1, A2AKM2, Q8BG85, Q9CPS2
      UniProtKB/TrEMBL
      F7CPS1
      Conserved Domains (1) summary
      pfam04387
      Location:65 → 223
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    3. XM_006538192.4 → XP_006538255.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform X2

      UniProtKB/TrEMBL
      F7CPS1
      Conserved Domains (1) summary
      pfam04387
      Location:65 → 205
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AKM2.2 GenPept UniProtKB/Swiss-Prot:A2AKM2

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