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    STY46 ACT-like protein tyrosine kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830003, updated on 18-Sep-2024

    Summary

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    Official Symbol
    STY46
    Official Full Name
    ACT-like protein tyrosine kinase family protein
    Primary source
    TAIR:AT4G38470
    Locus tag
    AT4G38470
    See related
    Araport:AT4G38470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F20M13.30; F20M13_30; serine/threonine/tyrosine kinase 46
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    Genomic context

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    See STY46 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    15
    Sequence:
    Chromosome: 4; NC_003075.7 (17998896..18003757)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene geranylgeranyl reductase Neighboring gene ncRNA Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene chromatin-remodeling complex subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Cytosolic Protein Kinase STY46 in Arabidopsis thaliana is Involved in Plant Growth and Abiotic Stress Response. Dong S, et al. Plants (Basel), 2020 Jan 2. PMID 31906450, Free PMC Article
    2. Multiple Kinases Can Phosphorylate the N-Terminal Sequences of Mitochondrial Proteins in Arabidopsis thaliana. Law YS, et al. Front Plant Sci, 2018. PMID 30042778, Free PMC Article
    3. The ACT domain in chloroplast precursor-phosphorylating STY kinases binds metabolites and allosterically regulates kinase activity. Eisa A, et al. J Biol Chem, 2019 Nov 15. PMID 31594863, Free PMC Article
    4. The cytosolic kinases STY8, STY17, and STY46 are involved in chloroplast differentiation in Arabidopsis. Lamberti G, et al. Plant Physiol, 2011 Sep. PMID 21799034, Free PMC Article
    5. A protein kinase family in Arabidopsis phosphorylates chloroplast precursor proteins. Martin T, et al. J Biol Chem, 2006 Dec 29. PMID 17090544

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ACT domain in chloroplast precursor-phosphorylating STY8, STY17, and STY46 kinases regulates activity and substrate binding.
      Title: The ACT domain in chloroplast precursor-phosphorylating STY kinases binds metabolites and allosterically regulates kinase activity.
    2. The protein kinase AT4G38470 could represent a subunit of a regulatory network involved in the cytosolic events of chloroplast protein import.
      Title: A protein kinase family in Arabidopsis phosphorylates chloroplast precursor proteins.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001342498.1
    NM_001342499.1
    NM_120008.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine/tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within chloroplast organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ACT-like protein tyrosine kinase family protein
    NP_568041.1
    • ACT-like protein tyrosine kinase family protein; FUNCTIONS IN: protein serine/threonine/tyrosine kinase activity, protein kinase activity; INVOLVED IN: protein amino acid phosphorylation, metabolic process; LOCATED IN: cytosol; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase domain (InterPro:IPR002290), Amino acid-binding ACT (InterPro:IPR002912), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Serine/threonine protein kinase-like, ATMRK (InterPro:IPR015783), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: ACT-like protein tyrosine kinase family protein (TAIR:AT4G35780.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17998896..18003757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120008.2 → NP_568041.1  ACT-like protein tyrosine kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568041.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JTP5, Q56Z78, Q9SZM7
      UniProtKB/TrEMBL
      A0A178V3V7, A0A5S9XZR8, A0A654FWP1
      Conserved Domains (2) summary
      cd13999
      Location:296 → 539
      STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases
      cl09141
      Location:176 → 241
      ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme

    2. NM_001342499.1 → NP_001328293.1  ACT-like protein tyrosine kinase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V3V7, A0A1P8B481

    3. NM_001342498.1 → NP_001328294.1  ACT-like protein tyrosine kinase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V3V7, A0A1P8B466
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JTP5.1

    Gene LinkOut

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