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    MDH malate dehydrogenase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823906, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MDH
    Official Full Name
    malate dehydrogenase
    Primary source
    TAIR:AT3G47520
    Locus tag
    AT3G47520
    See related
    Araport:AT3G47520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    malate dehydrogenase; MALATE DEHYDROGENASE; plastidic NAD-dependent malate dehydrogenase; pNAD-MDH
    Summary
    Encodes a protein with NAD-dependent malate dehydrogenase activity, located in chloroplasts.
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    Genomic context

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    See MDH in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (17512816..17515155)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene cycling DOF factor 3 Neighboring gene uncharacterized protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene ncRNA Neighboring gene Chitinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Redox regulation of NADP-malate dehydrogenase is vital for land plants under fluctuating light environment. Yokochi Y, et al. Proc Natl Acad Sci U S A, 2021 Feb 9. PMID 33531363, Free PMC Article
    2. Cysteine oxidation as a regulatory mechanism of Arabidopsis plastidial NAD-dependent malate dehydrogenase. Cosse M, et al. Physiol Plant, 2024 May-Jun. PMID 38741259
    3. The plastid-localized NAD-dependent malate dehydrogenase is crucial for energy homeostasis in developing Arabidopsis thaliana seeds. Selinski J, et al. Mol Plant, 2014 Jan. PMID 24198233
    4. Plastidial NAD-Dependent Malate Dehydrogenase: A Moonlighting Protein Involved in Early Chloroplast Development through Its Interaction with an FtsH12-FtsHi Protease Complex. Schreier TB, et al. Plant Cell, 2018 Aug. PMID 29934433, Free PMC Article
    5. Plastidial NAD-dependent malate dehydrogenase is critical for embryo development and heterotrophic metabolism in Arabidopsis. Beeler S, et al. Plant Physiol, 2014 Mar. PMID 24453164, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cysteine oxidation as a regulatory mechanism of Arabidopsis plastidial NAD-dependent malate dehydrogenase.
      Title: Cysteine oxidation as a regulatory mechanism of Arabidopsis plastidial NAD-dependent malate dehydrogenase.
    2. Redox regulation of NADP-malate dehydrogenase is vital for land plants under fluctuating light environment.
      Title: Redox regulation of NADP-malate dehydrogenase is vital for land plants under fluctuating light environment.
    3. CytMDH1 oxidation affects the kinetics, secondary structure, and thermodynamic stability of cytMDH1. Moreover, MS analyses and comparison of crystal structures between the reduced and H2O2-treated cytMDH1 further show that thioredoxin-reversible homodimerization of cytMDH1 through Cys330 disulfide formation protects the protein from overoxidation.
      Title: Self-protection of cytosolic malate dehydrogenase against oxidative stress in Arabidopsis.
    4. Purification and characterization of the plastid-localized NAD-dependent malate dehydrogenase from Arabidopsis thaliana
      Title: Purification and characterization of the plastid-localized NAD-dependent malate dehydrogenase from Arabidopsis thaliana.
    5. The critical role of plastidial NAD-specific MDH isoform in Arabidopsis (Arabidopsis thaliana) plants, is reported.
      Title: Plastidial NAD-dependent malate dehydrogenase is critical for embryo development and heterotrophic metabolism in Arabidopsis.
    6. Arabidopsis thaliana mutants lacking the NADP-malate dehydrogenase have lost the reversible inactivation of catalase activity and the increase in H2O2 levels when exposed to high light.
      Title: Putative role of the malate valve enzyme NADP-malate dehydrogenase in H2O2 signalling in Arabidopsis.
    7. plastid-localized NAD-dependent malate dehydrogenase is crucial for energy homeostasis in developing Arabidopsis thaliana seeds
      Title: The plastid-localized NAD-dependent malate dehydrogenase is crucial for energy homeostasis in developing Arabidopsis thaliana seeds.
    8. mMDH has a role in maximizing photorespiratory rate.
      Title: Mitochondrial malate dehydrogenase lowers leaf respiration and alters photorespiration and plant growth in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_114620.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-malate dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chloroplast protein-transporting ATPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in malate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein import into chloroplast stroma IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ycf2/FtsHi complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plastid HDA PubMed 
    located_in plastid stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stromule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    malate dehydrogenase
    NP_190336.1
    • malate dehydrogenase (MDH); FUNCTIONS IN: in 6 functions; INVOLVED IN: response to cold; LOCATED IN: in 8 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), Malate dehydrogenase, NAD-dependent, eukaryote/gamma proteobacteria (InterPro:IPR010097), NAD(P)-binding domain (InterPro:IPR016040), L-lactate/malate dehydrogenase (InterPro:IPR001557), Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: peroxisomal NAD-malate dehydrogenase 1 (TAIR:AT2G22780.1); Has 17295 Blast hits to 17293 proteins in 5537 species: Archae - 237; Bacteria - 12026; Metazoa - 1437; Fungi - 394; Plants - 805; Viruses - 0; Other Eukaryotes - 2396 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17512816..17515155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114620.3 → NP_190336.1  malate dehydrogenase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190336.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81844, Q9SN86
      UniProtKB/TrEMBL
      A0A178VF16, A0A5S9XJD0, A0A654FEK4
      Conserved Domains (1) summary
      PLN00106
      Location:80 → 389
      PLN00106; malate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SN86.1

    Gene LinkOut

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