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    UPL4 ubiquitin-protein ligase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831758, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UPL4
    Official Full Name
    ubiquitin-protein ligase 4
    Primary source
    TAIR:AT5G02880
    Locus tag
    AT5G02880
    See related
    Araport:AT5G02880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F9G14.190; F9G14_190; ubiquitin-protein ligase 4
    Summary
    encodes a ubiquitin-protein ligase containing a HECT domain. There are six other HECT-domain UPLs in Arabidopsis.
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    Genomic context

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    See UPL4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (661936..669124)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L4/L1 family Neighboring gene ncRNA Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene cytochrome P450, family 96, subfamily A, polypeptide 13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The HECT ubiquitin-protein ligase (UPL) family in Arabidopsis: UPL3 has a specific role in trichome development. Downes BP, et al. Plant J, 2003 Sep. PMID 12969426
    2. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_120366.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-protein ligase 4
    NP_195908.1
    • ubiquitin-protein ligase 4 (UPL4); CONTAINS InterPro DOMAIN/s: Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024), HECT (InterPro:IPR000569); BEST Arabidopsis thaliana protein match is: HEAT repeat; HECT-domain (ubiquitin-transferase) (TAIR:AT4G38600.1); Has 5635 Blast hits to 5003 proteins in 272 species: Archae - 0; Bacteria - 11; Metazoa - 3196; Fungi - 992; Plants - 513; Viruses - 0; Other Eukaryotes - 923 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      661936..669124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001342678.1 → NP_001331961.1  ubiquitin-protein ligase 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UHV4, A0A1P8BFE7

    2. NM_120366.4 → NP_195908.1  ubiquitin-protein ligase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195908.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LYZ7
      UniProtKB/TrEMBL
      A0A654FY97
      Conserved Domains (5) summary
      smart00119
      Location:1136 → 1497
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00020
      Location:156 → 264
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00078
      Location:1114 → 1500
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00044
      Location:277 → 303
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:156 → 181
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LYZ7.1

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