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    Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831088, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Rho GTPase activation protein (RhoGAP) with PH domain-containing protein
    Primary source
    TAIR:AT5G12150
    Locus tag
    AT5G12150
    See related
    Araport:AT5G12150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MXC9.11; MXC9_11
    Summary
    Encodes a protein with similarity to REN1, a Rho GTPase activating protein.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    22
    Sequence:
    Chromosome: 5; NC_003076.8 (3924107..3930441, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene integral membrane TerC family protein Neighboring gene cystatin-1 Neighboring gene CRT (chloroquine-resistance transporter)-like transporter 3 Neighboring gene calcium-dependent protein kinase 17

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Putative RopGAPs impact division plane selection and interact with kinesin-12 POK1. Stöckle D, et al. Nat Plants, 2016 Aug 8. PMID 27501519
    2. A tip-localized RhoGAP controls cell polarity by globally inhibiting Rho GTPase at the cell apex. Hwang JU, et al. Curr Biol, 2008 Dec 23. PMID 19108776, Free PMC Article
    3. Learning the lipid language of plant signalling. van Leeuwen W, et al. Trends Plant Sci, 2004 Aug. PMID 15358268
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. loss of PHGAP function interferes with division plane selection in proliferative cell divisions. [PH-GAP1]
      Title: Putative RopGAPs impact division plane selection and interact with kinesin-12 POK1.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001125741.1
    NM_121253.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell plate formation involved in plant-type cell wall biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with preprophase band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rho GTPase activation protein (RhoGAP) with PH domain-containing protein
    NP_001119213.1
    • Rho GTPase activation protein (RhoGAP) with PH domain; FUNCTIONS IN: Rho GTPase activator activity, phosphoinositide binding; INVOLVED IN: signal transduction; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Rho GTPase activation protein (InterPro:IPR008936), Pleckstrin homology (InterPro:IPR001849), RhoGAP (InterPro:IPR000198); BEST Arabidopsis thaliana protein match is: Rho GTPase activation protein (RhoGAP) with PH domain (TAIR:AT5G19390.3); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_196776.1
    • Rho GTPase activation protein (RhoGAP) with PH domain; FUNCTIONS IN: Rho GTPase activator activity, phosphoinositide binding; INVOLVED IN: signal transduction; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Rho GTPase activation protein (InterPro:IPR008936), Pleckstrin homology (InterPro:IPR001849), RhoGAP (InterPro:IPR000198); BEST Arabidopsis thaliana protein match is: Rho GTPase activation protein (RhoGAP) with PH domain (TAIR:AT5G19390.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3924107..3930441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121253.5 → NP_196776.1  Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196776.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WM40, Q9FMP8
      UniProtKB/TrEMBL
      A0A178UC38, A0A5S9Y431
      Conserved Domains (4) summary
      TIGR02168
      Location:566 → 745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00169
      Location:19 → 116
      PH; PH domain
      pfam00620
      Location:181 → 325
      RhoGAP; RhoGAP domain
      pfam14389
      Location:600 → 678
      Lzipper-MIP1; Leucine-zipper of ternary complex factor MIP1

    2. NM_001125741.1 → NP_001119213.1  Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y431, B3H5D4
      Conserved Domains (4) summary
      smart00233
      Location:19 → 116
      PH; Pleckstrin homology domain
      pfam00169
      Location:19 → 116
      PH; PH domain
      pfam00620
      Location:181 → 325
      RhoGAP; RhoGAP domain
      pfam14389
      Location:601 → 680
      Lzipper-MIP1; Leucine-zipper of ternary complex factor MIP1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FMP8.1

    Gene LinkOut

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