PDR2 phosphate deficiency response 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PDR2
Official Full Name: phosphate deficiency response 2
Primary source: TAIR:AT5G23630
Locus tag: AT5G23630
See related: Araport:AT5G23630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: MALE GAMETOGENESIS IMPAIRED ANTHERS; MIA; MQM1.11; MQM1_11; phosphate deficiency response 2; PI DEFICIENCY RESPONSE 2
Summary: A member of the eukaryotic type V subfamily (P5) of P-type ATPase cation pumps; MIA is most similar to the human P5 ATPase ATY2(44% identity) and to Spf1p from S. cerevisiae (41% identity). Highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. T-DNA insertional mutants of MIA suffer from imbalances in cation homeostasis and exhibit a severe reduction in fertility. Mutant microspores fail to separate from tetrads and pollen grains are fragile with an abnormal morphology and altered cell wall structure. MIA is also named PDR2 and was shown to be required for proper expression of SCARECROW (SCR), a key regulator of root patterning, and for stem-cell maintenance in Pi-deprived roots.
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Genomic context

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See PDR2 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 22

Sequence:: Chromosome: 5; NC_003076.8 (7960478..7968197, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the LPR1-PDR2 module facilitates, upon Phosphate limitation, cell-specific apoplastic iron and callose deposition in the meristem and elongation zone of primary roots.
Title: Iron-dependent callose deposition adjusts root meristem maintenance to phosphate availability.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_122268.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ATPase-coupled monoatomic cation transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables P-type transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to phosphate starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular monoatomic cation homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meristem maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen germination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: phosphate deficiency response 2

NP_197752.1

phosphate deficiency response 2 (PDR2); FUNCTIONS IN: cation-transporting ATPase activity; INVOLVED IN: in 6 processes; LOCATED IN: endoplasmic reticulum, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, unknown pump specificity (type V) (InterPro:IPR006544), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: calcium ATPase 2 (TAIR:AT4G37640.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

7960478..7968197 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122268.5 → NP_197752.1 phosphate deficiency response 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197752.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LT02

UniProtKB/TrEMBL

A0A178UPV3, A0A5S9Y6J9

Conserved Domains (4) summary

COG4087
Location:747 → 832

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01657
Location:36 → 1136

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:237 → 476

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:544 → 615

Cation_ATPase; Cation transport ATPase (P-type)