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    FPS1 farnesyl diphosphate synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834828, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FPS1
    Official Full Name
    farnesyl diphosphate synthase 1
    Primary source
    TAIR:AT5G47770
    Locus tag
    AT5G47770
    See related
    Araport:AT5G47770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    farnesyl diphosphate synthase 1; FARNESYL DIPHOSPHATE SYNTHASE 1; MCA23.9; MCA23_9
    Summary
    Encodes a protein with farnesyl diphosphate synthase activity.
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    Genomic context

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    See FPS1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (19345110..19347677)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Sec14p-like phosphatidylinositol transfer family protein Neighboring gene ncRNA Neighboring gene Adenine nucleotide alpha hydrolases-like superfamily protein Neighboring gene D6 protein kinase like 2 Neighboring gene 2-phosphoglycolate phosphatase 2 Neighboring gene galacturonosyltransferase 4 Neighboring gene miscRNA Neighboring gene SMAD/FHA domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of farnesyl diphosphate synthase in Arabidopsis mitochondria triggers light-dependent lesion formation and alters cytokinin homeostasis. Manzano D, et al. Plant Mol Biol, 2006 May. PMID 16786301
    2. Cloning of an Arabidopsis thaliana cDNA coding for farnesyl diphosphate synthase by functional complementation in yeast. Delourme D, et al. Plant Mol Biol, 1994 Dec. PMID 7858223
    3. Suppressing Farnesyl Diphosphate Synthase Alters Chloroplast Development and Triggers Sterol-Dependent Induction of Jasmonate- and Fe-Related Responses. Manzano D, et al. Plant Physiol, 2016 Sep. PMID 27382138, Free PMC Article
    4. Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds. Keim V, et al. PLoS One, 2012. PMID 23145086, Free PMC Article
    5. Formation of monoterpenes in Antirrhinum majus and Clarkia breweri flowers involves heterodimeric geranyl diphosphate synthases. Tholl D, et al. Plant Cell, 2004 Apr. PMID 15031409, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Farnesyl diphosphate synthase (FPS) single fps1 and fps2 knockout mutants are phenotypically indistinguishable from wild-type plants, while fps1/fps2 double mutants are embryo lethal.
      Title: Suppressing Farnesyl Diphosphate Synthase Alters Chloroplast Development and Triggers Sterol-Dependent Induction of Jasmonate- and Fe-Related Responses.
    2. Expression analysis of FPS genes in seeds showed that FPS1 and FPS2 display complementary patterns of expression particularly at late stages of seed development, which suggests that Arabidopsis seeds have two spatially segregated sources of FPP
      Title: Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds.
    3. Overexpression of FPS1L leads to mitochondrial dysfunction that renders plants more sensitive to the oxidative stress induced by continuous light. [FPS1L]
      Title: Overexpression of farnesyl diphosphate synthase in Arabidopsis mitochondria triggers light-dependent lesion formation and alters cytokinin homeostasis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124151.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dimethylallyltranstransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dimethylallyltranstransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables geranyltranstransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables geranyltranstransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within farnesyl diphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in farnesyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in geranyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    farnesyl diphosphate synthase 1
    NP_199588.1
    • farnesyl diphosphate synthase 1 (FPS1); FUNCTIONS IN: dimethylallyltranstransferase activity, geranyltranstransferase activity; INVOLVED IN: farnesyl diphosphate biosynthetic process, isoprenoid biosynthetic process; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Terpenoid synthase (InterPro:IPR008949), Polyprenyl synthetase (InterPro:IPR000092); BEST Arabidopsis thaliana protein match is: farnesyl diphosphate synthase 2 (TAIR:AT4G17190.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19345110..19347677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124151.3 → NP_199588.1  farnesyl diphosphate synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199588.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09152, Q42573, Q8W504, Q93Y84
      UniProtKB/TrEMBL
      A0A178ULK1
      Conserved Domains (1) summary
      pfam00348
      Location:82 → 343
      polyprenyl_synt; Polyprenyl synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09152.2

    Gene LinkOut

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