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    haloacid dehalogenase-like hydrolase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835466, updated on 18-Sep-2024

    Summary

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    Official Full Name
    haloacid dehalogenase-like hydrolase family protein
    Primary source
    TAIR:AT5G53850
    Locus tag
    AT5G53850
    See related
    Araport:AT5G53850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DEHYDRATASE-ENOLASE-PHOSPHATASE-COMPLEX 1; DEP1; K19P17.1; K19P17_1
    Summary
    Encodes a trifunctional dehydratase / enolase / phosphatase involved in the methionine salvage.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (21860860..21865150, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene VQ motif-containing protein Neighboring gene F-box/RNI-like/FBD-like domains-containing protein Neighboring gene embryo defective 2737 Neighboring gene early nodulin-like protein 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phloem-specific expression of Yang cycle genes and identification of novel Yang cycle enzymes in Plantago and Arabidopsis. Pommerrenig B, et al. Plant Cell, 2011 May. PMID 21540433, Free PMC Article
    2. Profiling of the Receptor for Activated C Kinase 1a (RACK1a) interaction network in Arabidopsis thaliana. Guo J, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31606202
    3. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124764.2
    NM_203202.3
    NM_203203.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acireductone synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylthioribulose 1-phosphate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    haloacid dehalogenase-like hydrolase family protein
    NP_200196.2
    • haloacid dehalogenase-like hydrolase family protein; FUNCTIONS IN: hydrolase activity, ion binding, methylthioribulose 1-phosphate dehydratase activity, metal ion binding; INVOLVED IN: L-methionine salvage; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Class II aldolase/adducin, N-terminal (InterPro:IPR001303), Methylthioribulose-1-phosphate dehydratase (InterPro:IPR017714); Has 2955 Blast hits to 2952 proteins in 928 species: Archae - 33; Bacteria - 2121; Metazoa - 295; Fungi - 289; Plants - 67; Viruses - 0; Other Eukaryotes - 150 (source: NCBI BLink).
    NP_974931.1
    • haloacid dehalogenase-like hydrolase family protein; FUNCTIONS IN: in 7 functions; INVOLVED IN: L-methionine salvage from methylthioadenosine, L-methionine salvage, metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), 2,3-diketo-5-methylthio-1-phosphopentane phosphatase (InterPro:IPR010041), Class II aldolase/adducin, N-terminal (InterPro:IPR001303), HAD-superfamily hydrolase, subfamily IA, variant 1 (InterPro:IPR006439), Methylthioribulose-1-phosphate dehydratase (InterPro:IPR017714); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_974932.1
    • haloacid dehalogenase-like hydrolase family protein; FUNCTIONS IN: hydrolase activity, ion binding, methylthioribulose 1-phosphate dehydratase activity, metal ion binding; INVOLVED IN: L-methionine salvage; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Class II aldolase/adducin, N-terminal (InterPro:IPR001303), Methylthioribulose-1-phosphate dehydratase (InterPro:IPR017714); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21860860..21865150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001345069.1 → NP_001330483.1  haloacid dehalogenase-like hydrolase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178URU2, A0A1P8BAY5, A0A654GB83
      Conserved Domains (2) summary
      TIGR03328
      Location:28 → 250
      salvage_mtnB; methylthioribulose-1-phosphate dehydratase
      cd01629
      Location:283 → 504
      HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

    2. NM_001345068.1 → NP_001330484.1  haloacid dehalogenase-like hydrolase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UQC1, A0A178URU2, A0A1P8BB04, A0A384L6V5
      Conserved Domains (2) summary
      cd01629
      Location:178 → 399
      HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep
      cl00214
      Location:26 → 145
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    3. NM_001345070.1 → NP_001330482.1  haloacid dehalogenase-like hydrolase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178URU2, A0A1P8BAY8

    4. NM_203202.3 → NP_974931.1  haloacid dehalogenase-like hydrolase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974931.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WP93, Q9FN41
      UniProtKB/TrEMBL
      A0A178UQ47
      Conserved Domains (2) summary
      TIGR03328
      Location:28 → 234
      salvage_mtnB; methylthioribulose-1-phosphate dehydratase
      cd01629
      Location:267 → 488
      HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

    5. NM_203203.2 → NP_974932.1  haloacid dehalogenase-like hydrolase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974932.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JYQ6
      Conserved Domains (2) summary
      TIGR03328
      Location:28 → 250
      salvage_mtnB; methylthioribulose-1-phosphate dehydratase
      cl21460
      Location:282 → 417
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    6. NM_124764.2 → NP_200196.2  haloacid dehalogenase-like hydrolase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200196.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JYQ5
      Conserved Domains (2) summary
      TIGR03328
      Location:28 → 234
      salvage_mtnB; methylthioribulose-1-phosphate dehydratase
      cl21460
      Location:266 → 401
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FN41.1

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