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    GRIK2 geminivirus rep interacting kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836176, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GRIK2
    Official Full Name
    geminivirus rep interacting kinase 2
    Primary source
    TAIR:AT5G60550
    Locus tag
    AT5G60550
    See related
    Araport:AT5G60550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSNAK1; geminivirus rep interacting kinase 2; MUF9.13; MUF9_13
    Summary
    Encodes a geminivirus Rep interacting kinase (GRIK; GRIK1/AT3G45240, GRIK2/AT5G60550). GRIKs are SnRK1 (SNF1-related kinases) activating kinases. Both GRIKs specifically bind to the SnRK1 catalytic subunit and phosphorylate the equivalent threonine residue in its activation loop in vitro.
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    Genomic context

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    See GRIK2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (24339229..24342590)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene late embryogenesis abundant protein-related / LEA protein-like protein Neighboring gene pyridoxine biosynthesis 2 Neighboring gene Defensin-like (DEFL) family protein Neighboring gene F-box and associated interaction domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cross-phosphorylation between Arabidopsis thaliana sucrose nonfermenting 1-related protein kinase 1 (AtSnRK1) and its activating kinase (AtSnAK) determines their catalytic activities. Crozet P, et al. J Biol Chem, 2010 Apr 16. PMID 20164192, Free PMC Article
    2. DOMAIN OF UNKNOWN FUNCTION581-9 negatively regulates SnRK1 kinase activity. Bortlik J, et al. Plant Physiol, 2024 Feb 29. PMID 37936321, Free PMC Article
    3. Arabidopsis protein kinases GRIK1 and GRIK2 specifically activate SnRK1 by phosphorylating its activation loop. Shen W, et al. Plant Physiol, 2009 Jun. PMID 19339507, Free PMC Article
    4. Geminivirus infection up-regulates the expression of two Arabidopsis protein kinases related to yeast SNF1- and mammalian AMPK-activating kinases. Shen W, et al. Plant Physiol, 2006 Dec. PMID 17041027, Free PMC Article
    5. DNA sequences from Arabidopsis, which encode protein kinases and function as upstream regulators of Snf1 in yeast. Hey S, et al. J Biol Chem, 2007 Apr 6. PMID 17237223

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GRIKs are SnRK1 activating kinases.
      Title: Arabidopsis protein kinases GRIK1 and GRIK2 specifically activate SnRK1 by phosphorylating its activation loop.
    2. Geminivirus Rep-interacting kinase 1, GRIK1 and GRIK2, interact with the geminivirus replication protein AL1 function by mediating one or more processes during early plant development and geminivirus infection by activating SNF1-related kinases. [GRIK2]
      Title: Geminivirus infection up-regulates the expression of two Arabidopsis protein kinases related to yeast SNF1- and mammalian AMPK-activating kinases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Miscellaneous features

    • Loc: 24339842-24339919 AT5G60550.uORF1
    NM_125448.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    geminivirus rep interacting kinase 2
    NP_200863.2
    • geminivirus rep interacting kinase 2 (GRIK2); CONTAINS InterPro DOMAIN/s: Calcium/calmodulin-dependent protein kinase kinase (InterPro:IPR020657), Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: geminivirus rep interacting kinase 1 (TAIR:AT3G45240.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24339229..24342590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125448.4 → NP_200863.2  geminivirus rep interacting kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200863.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5HZ38, Q8LPG6, Q9FKJ2
      UniProtKB/TrEMBL
      A0A178UN27, A0A5S9YFZ4, A0A654GCV1, A0A7G2FHP3
      Conserved Domains (1) summary
      cd14008
      Location:113 → 370
      STKc_LKB1_CaMKK; Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZ38.1

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