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    KAC2 kinesin like protein for actin based chloroplast movement 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836671, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KAC2
    Official Full Name
    kinesin like protein for actin based chloroplast movement 2
    Primary source
    TAIR:AT5G65460
    Locus tag
    AT5G65460
    See related
    Araport:AT5G65460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    KCA2; kinesin CDKA ;1 associated 2; kinesin like protein for actin based chloroplast movement 2; MNA5.20; MNA5_20
    Summary
    Kinesin that binds cyclin-dependent kinase CDKA;1 as homodimer or as heterodimer with KCA1
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    Genomic context

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    See KAC2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    24
    Sequence:
    Chromosome: 5; NC_003076.8 (26161624..26169191, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene ubiquitin-specific protease 17 Neighboring gene O-fucosyltransferase family protein Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two kinesin-like proteins mediate actin-based chloroplast movement in Arabidopsis thaliana. Suetsugu N, et al. Proc Natl Acad Sci U S A, 2010 May 11. PMID 20418504, Free PMC Article
    2. Light-Induced Movements of Chloroplasts and Nuclei Are Regulated in Both Cp-Actin-Filament-Dependent and -Independent Manners in Arabidopsis thaliana. Suetsugu N, et al. PLoS One, 2016. PMID 27310016, Free PMC Article
    3. A plant-specific subclass of C-terminal kinesins contains a conserved a-type cyclin-dependent kinase site implicated in folding and dimerization. Vanstraelen M, et al. Plant Physiol, 2004 Jul. PMID 15247388, Free PMC Article
    4. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article
    5. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results indicate that CHUP1 and KAC1/KAC2 function somewhat independently, but interdependently mediate both chloroplast and nuclear photorelocation movements in Arabidopsis cells.
      Title: Light-Induced Movements of Chloroplasts and Nuclei Are Regulated in Both Cp-Actin-Filament-Dependent and -Independent Manners in Arabidopsis thaliana.
    2. Two kinesin-like proteins, KAC1 and KAC2, are essential for chloroplasts to move via cp-actin filaments and anchor to the plasma membrane. [KAC2]
      Title: Two kinesin-like proteins mediate actin-based chloroplast movement in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_125944.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast accumulation movement IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chloroplast accumulation movement IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within chloroplast avoidance movement IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chloroplast avoidance movement IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear migration along microfilament IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular anatomical structure IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin like protein for actin based chloroplast movement 2
    NP_201349.3
    • kinesin like protein for actin based chloroplast movement 2 (KAC2); FUNCTIONS IN: microtubule binding, protein binding, microtubule motor activity; INVOLVED IN: chloroplast avoidance movement, chloroplast accumulation movement; LOCATED IN: cytosol, plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: kinesin like protein for actin based chloroplast movement 1 (TAIR:AT5G10470.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26161624..26169191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001345690.1 → NP_001331384.1  kinesin like protein for actin based chloroplast movement 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UC07, A0A1P8BDQ0, A0A5S9YIF2, A0A654GET4
      Conserved Domains (2) summary
      TIGR02169
      Location:459 → 649
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam00225
      Location:144 → 452
      Kinesin; Kinesin motor domain

    2. NM_001345688.1 → NP_001331380.1  kinesin like protein for actin based chloroplast movement 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UC07, A0A1P8BDS9, A0A5S9YIF2

    3. NM_001345689.1 → NP_001331383.1  kinesin like protein for actin based chloroplast movement 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UC07, A0A1P8BDP7, A0A5S9YIF2

    4. NM_001345691.1 → NP_001331382.1  kinesin like protein for actin based chloroplast movement 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BDN5, A0A5S9YIF2

    5. NM_001345692.1 → NP_001331381.1  kinesin like protein for actin based chloroplast movement 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UC07, A0A1P8BDP2, A0A5S9YIF2

    6. NM_125944.3 → NP_201349.3  kinesin like protein for actin based chloroplast movement 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201349.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FKP4
      UniProtKB/TrEMBL
      A0A178UC07, A0A5S9YIF2
      Conserved Domains (2) summary
      cl22853
      Location:136 → 453
      Motor_domain; Myosin and Kinesin motor domain
      pfam00225
      Location:144 → 452
      Kinesin; Kinesin motor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FKP4.1

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