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    AER alkenal reductase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831560, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AER
    Official Full Name
    alkenal reductase
    Primary source
    TAIR:AT5G16970
    Locus tag
    AT5G16970
    See related
    Araport:AT5G16970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    alkenal reductase; AT-AER; F2K13.120; F2K13_120
    Summary
    encodes a 2-alkenal reductase (EC 1.3.1.74), plays a key role in the detoxification of reactive carbonyls
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    Genomic context

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    See AER in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (5575973..5578086, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene krueppel-like factor Neighboring gene ncRNA Neighboring gene Zinc-binding dehydrogenase family protein Neighboring gene Zinc-binding dehydrogenase family protein Neighboring gene Zinc-binding dehydrogenase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanistic and structural studies of apoform, binary, and ternary complexes of the Arabidopsis alkenal double bond reductase At5g16970. Youn B, et al. J Biol Chem, 2006 Dec 29. PMID 17028190
    2. Protection against photooxidative injury of tobacco leaves by 2-alkenal reductase. Detoxication of lipid peroxide-derived reactive carbonyls. Mano J, et al. Plant Physiol, 2005 Dec. PMID 16299173, Free PMC Article
    3. CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset. Boudolf V, et al. Plant Physiol, 2009 Jul. PMID 19458112, Free PMC Article
    4. Arabidopsis thaliana NADPH oxidoreductase homologs confer tolerance of yeasts toward the thiol-oxidizing drug diamide. Babiychuk E, et al. J Biol Chem, 1995 Nov 3. PMID 7592828
    5. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal study of Arabidopsis alkenal double bond reductase encoded by At5g16970 determines that it belongs to the zinc-independent medium chain dehydrogenase/reductase superfamily.
      Title: Mechanistic and structural studies of apoform, binary, and ternary complexes of the Arabidopsis alkenal double bond reductase At5g16970.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_121703.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 2-alkenal reductase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    alkenal reductase
    NP_197199.1
    • alkenal reductase (AER); FUNCTIONS IN: 2-alkenal reductase activity; INVOLVED IN: response to oxidative stress, response to cadmium ion, response to cyclopentenone; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: GroES-like (InterPro:IPR011032), Polyketide synthase, enoylreductase (InterPro:IPR020843), NAD(P)-binding domain (InterPro:IPR016040), Alcohol dehydrogenase, C-terminal (InterPro:IPR013149), Alcohol dehydrogenase superfamily, zinc-containing (InterPro:IPR002085); BEST Arabidopsis thaliana protein match is: Zinc-binding dehydrogenase family protein (TAIR:AT5G17000.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5575973..5578086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121703.4 → NP_197199.1  alkenal reductase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197199.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39172, Q501A9, Q8L865
      UniProtKB/TrEMBL
      A0A178U6Z5, A0A5S9Y577, A0A654G257
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39172.1

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