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    ANNAT4 annexin 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818457, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ANNAT4
    Official Full Name
    annexin 4
    Primary source
    TAIR:AT2G38750
    Locus tag
    AT2G38750
    See related
    Araport:AT2G38750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    annexin 4; ANNEXIN 4; AtANN4; T6A23.5; T6A23_5
    Summary
    Annexins are a family of calcium dependent membrane binding proteins though to be involved in Golgi mediated secretion. This is one of four annexins identified in Arabidopsis.
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    Genomic context

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    See ANNAT4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_003071.7 (16196265..16198832, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene annexin 3 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpressed Arabidopsis Annexin4 accumulates in inclusion body-like structures. Khachatoorian C, et al. Acta Histochem, 2015 Apr. PMID 25818562, Free PMC Article
    2. Arabidopsis annexins AnnAt1 and AnnAt4 interact with each other and regulate drought and salt stress responses. Huh SM, et al. Plant Cell Physiol, 2010 Sep. PMID 20656895
    3. Proteomic identification of annexins, calcium-dependent membrane binding proteins that mediate osmotic stress and abscisic acid signal transduction in Arabidopsis. Lee S, et al. Plant Cell, 2004 Jun. PMID 15161963, Free PMC Article
    4. MYB30 transcription factor regulates oxidative and heat stress responses through ANNEXIN-mediated cytosolic calcium signaling in Arabidopsis. Liao C, et al. New Phytol, 2017 Oct. PMID 28726305
    5. Expression profiling of the Arabidopsis annexin gene family during germination, de-etiolation and abiotic stress. Cantero A, et al. Plant Physiol Biochem, 2006 Jan. PMID 16531057

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MYB30 regulates oxidative and heat stress responses through calcium signaling, which is at least partially mediated by ANN1 and ANN4.[ANN4]
      Title: MYB30 transcription factor regulates oxidative and heat stress responses through ANNEXIN-mediated cytosolic calcium signaling in Arabidopsis.
    2. Annexin 4 fusion proteins form inclusion body-like aggreagates in Arabidopsis and may be artifacts of transgenic overexpression.
      Title: Overexpressed Arabidopsis Annexin4 accumulates in inclusion body-like structures.
    3. AnnAt1 and AnnAt4 interact with each other in a Ca2+-dependent manner and function to regulate responses to drought and salt stress.
      Title: Arabidopsis annexins AnnAt1 and AnnAt4 interact with each other and regulate drought and salt stress responses.
    4. results collectively suggest that AnnAt1 and AnnAt4 play important roles in osmotic stress and ABA signaling in a Ca2+-dependent manner
      Title: Proteomic identification of annexins, calcium-dependent membrane binding proteins that mediate osmotic stress and abscisic acid signal transduction in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_129432.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium ion binding NAS
    Non-traceable Author Statement
    more info
    		  
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in cell surface NAS
    Non-traceable Author Statement
    more info
    		  
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    annexin 4
    NP_181409.1
    • annexin 4 (ANNAT4); FUNCTIONS IN: calcium-dependent phospholipid binding, calcium ion binding; INVOLVED IN: in 6 processes; LOCATED IN: cell surface; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Annexin like protein (InterPro:IPR015472), Annexin repeat (InterPro:IPR018502), Annexin (InterPro:IPR001464); BEST Arabidopsis thaliana protein match is: annexin 8 (TAIR:AT5G12380.1); Has 2371 Blast hits to 2094 proteins in 191 species: Archae - 0; Bacteria - 0; Metazoa - 1728; Fungi - 90; Plants - 415; Viruses - 0; Other Eukaryotes - 138 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16196265..16198832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336725.1 → NP_001324877.1  annexin 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B1L4, A0A5S9X578

    2. NM_129432.3 → NP_181409.1  annexin 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181409.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZVJ6
      UniProtKB/TrEMBL
      A0A178VQU4, A0A5S9X578
      Conserved Domains (1) summary
      cl02574
      Location:90 → 155
      Annexin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZVJ6.1

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