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    Cts7 cathepsin 7 [ Mus musculus (house mouse) ]

    Gene ID: 56092, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cts7provided by MGI
    Official Full Name
    cathepsin 7provided by MGI
    Primary source
    MGI:MGI:1860262
    See related
    Ensembl:ENSMUSG00000021440 AllianceGenome:MGI:1860262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CTS1; Epcs24; Epcs71
    Summary
    Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Acts upstream of or within negative regulation of mitotic cell cycle and trophoblast giant cell differentiation. Located in several cellular components, including Golgi apparatus; endosome; and lysosome. Is expressed in embryo; extraembryonic component; heart; placenta; and primary trophoblast giant cell. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Cts7 in Genome Data Viewer
    Location:
    13 B2; 13 32.71 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61500275..61506010, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (61352461..61358196, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cathepsin 8, pseudogene Neighboring gene predicted gene 5664 Neighboring gene STARR-seq mESC enhancer starr_34748 Neighboring gene STARR-seq mESC enhancer starr_34749 Neighboring gene cathepsin 7, pseudogene Neighboring gene cathepsin M, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins. Oikawa D, et al. Biochem Biophys Res Commun, 2013 Apr 19. PMID 23541586
    2. Cathepsin proteases have distinct roles in trophoblast function and vascular remodelling. Screen M, et al. Development, 2008 Oct. PMID 18776147
    3. cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion. Hemberger M, et al. Dev Biol, 2000 Jun 1. PMID 10885754
    4. Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13. Deussing J, et al. Genomics, 2002 Feb. PMID 11829493
    5. Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development. Torregrosa-Carrión R, et al. Sci Adv, 2021 Nov 12. PMID 34767447, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within trophoblast giant cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cathepsin 7
    Names
    cathepsin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359387.1 → NP_001346316.1  cathepsin 7 preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY014779, BC064740, CT030645
      Consensus CDS
      CCDS26588.1
      UniProtKB/Swiss-Prot
      Q91ZF2, Q9JI84
      UniProtKB/TrEMBL
      A0A286YDP3
      Related
      ENSMUSP00000153603.2, ENSMUST00000224986.2
      Conserved Domains (2) summary
      smart00848
      Location:29 → 87
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      cd02248
      Location:113 → 329
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

    2. NM_019539.4 → NP_062412.1  cathepsin 7 preproprotein

      See identical proteins and their annotated locations for NP_062412.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC064740, CA536242, CT030645
      Consensus CDS
      CCDS26588.1
      UniProtKB/Swiss-Prot
      Q91ZF2, Q9JI84
      UniProtKB/TrEMBL
      A0A286YDP3
      Related
      ENSMUSP00000021892.6, ENSMUST00000021892.7
      Conserved Domains (2) summary
      smart00848
      Location:29 → 87
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      cd02248
      Location:113 → 329
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      61500275..61506010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZF2.1 GenPept UniProtKB/Swiss-Prot:Q91ZF2

    Gene LinkOut

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