CDC2 cell division control 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: CDC2
Official Full Name: cell division control 2
Primary source: TAIR:AT3G48750
Locus tag: AT3G48750
See related: Araport:AT3G48750
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CDC2A; CDC2AAT; CDK2; CDKA1; CDKA;1; cell division control 2; CYCLIN-DEPENDENT KINASE A;1; P34CDC2
Summary: A-type cyclin-dependent kinase. Together with its specific inhibitor, the Kip-related protein, KRP2 they regulate the mitosis-to-endocycle transition during leaf development. Dominant negative mutations abolish cell division. Loss of function phenotype has reduced fertility with failure to transmit via pollen. Pollen development is arrested at the second mitotic division. Expression is regulated by environmental and chemical signals. Part of the promoter is responsible for expression in trichomes. Functions as a positive regulator of cell proliferation during development of the male gametophyte, embryo and endosperm. Phosphorylation of threonine 161 is required for activation of its associated kinase.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See CDC2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 9

Sequence:: Chromosome: 3; NC_003074.8 (18071454..18074641)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDKD-dependent activation of CDKA;1 controls microtubule dynamics and cytokinesis during meiosis.
Title: CDKD-dependent activation of CDKA;1 controls microtubule dynamics and cytokinesis during meiosis.
The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls chromosome axis assembly during plant meiosis.
Title: The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls chromosome axis assembly during plant meiosis.
modulation of CDKA;1 kinase activity affects the number and placement of crossovers along the chromosome axis in a dose-dependent manner
Title: The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis.
Data show that phosphatidylcholine (PC) biosynthesis is repressed by disruption of the core cell cycle regulator CYCLIN-DEPENDENT KINASE A;1 (CDKA;1) and that this repression is reliant on PHOSPHATIDIC ACID PHOSPHOHYDROLASE (PAH).
Title: Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity.
Cyclin-dependent kinase A (CDKA) phosphorylates eukaryotic initiation factor 4A (eIF4A)eIF4A1 and eIF4A2 on a conserved threonine residue (threonine-164) within the RNA-binding motif.
Title: eIF4A RNA Helicase Associates with Cyclin-Dependent Protein Kinase A in Proliferating Cells and Is Modulated by Phosphorylation.
CDKA;1 and CYCD3;2 are required for the terminal division in the stomatal lineage.
Title: Requirement for A-type cyclin-dependent kinase and cyclins for the terminal division in the stomatal lineage of Arabidopsis.
Data indicate that the in vivo confirmation of substrates of CDKA;1 showing a direct link between cell proliferation and the control of the redox state.
Title: Identification of kinase substrates by bimolecular complementation assays.
The crucial function of CDKA;1 is the control of the plant Retinoblastoma homolog RBR1 and codepletion of RBR1 and CDKA;1 rescued most defects of cdka;1 mutants.
Title: Genetic framework of cyclin-dependent kinase function in Arabidopsis.
Expression of a dominant negative CDKA;1 allele under the control of the STM promoter perturbs post-embryonic development. Inhibition of CDK activity at the shoot apex results in premature differentiation of shoot apical meristem cells.
Title: Cyclin-dependent kinase activity maintains the shoot apical meristem cells in an undifferentiated state.
When a single cdka;1 sperm was delivered, either female gamete could be fertilized leading to similar proportions of seeds containing either a single endosperm or a single embryo.
Title: Sperm entry is sufficient to trigger division of the central cell but the paternal genome is required for endosperm development in Arabidopsis.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_114734.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within asymmetric cell division	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cytokinesis by cell plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gametophyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in guard mother cell cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in guard mother cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pollen development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle G1/S phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
involved_in symmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cortical microtubule, transverse to long axis	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in preprophase band	TAS Traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: cell division control 2

NP_566911.1

cell division control 2 (CDC2); FUNCTIONS IN: protein binding, protein kinase activity, cyclin-dependent protein kinase activity, kinase activity; INVOLVED IN: in 8 processes; LOCATED IN: in 6 components; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cyclin-dependent kinase B1;2 (TAIR:AT2G38620.2); Has 126125 Blast hits to 124135 proteins in 4221 species: Archae - 112; Bacteria - 14002; Metazoa - 46757; Fungi - 13170; Plants - 30525; Viruses - 484; Other Eukaryotes - 21075 (source: NCBI BLink).