U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    AUR2 ataurora2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817129, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    AUR2
    Official Full Name
    ataurora2
    Primary source
    TAIR:AT2G25880
    Locus tag
    AT2G25880
    See related
    Araport:AT2G25880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtAUR2; ataurora2; F17H15.9; F17H15_9
    Summary
    Encodes a member of a family of Ser/Thr kinases whose activities peak during cell division. Transcripts are abundant in tissues rich in dividing cells like roots and flowers but are low or absent in fully expanded leaves and stems. In interphase cells, the protein is predominantly nuclear. During mitosis, the protein associates with plant-specific cytoskeletal structures (preprophase band, phragmoplast, nascent cell plate) that are necessary for cytokinesis as well as with the microtubule spindle.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See AUR2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (11034652..11038191, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Nucleotidylyl transferase superfamily protein Neighboring gene poly(A) polymerase 2 Neighboring gene haloacid dehalogenase-like hydrolase family protein Neighboring gene Oleosin family protein Neighboring gene Zinc finger C-x8-C-x5-C-x3-H type family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The α-Aurora Kinases Function in Vascular Development in Arabidopsis. Lee KH, et al. Plant Cell Physiol, 2019 Jan 1. PMID 30329113
    2. Arabidopsis α Aurora kinases function in formative cell division plane orientation. Van Damme D, et al. Plant Cell, 2011 Nov. PMID 22045917, Free PMC Article
    3. Altered expression of Aurora kinases in Arabidopsis results in aneu- and polyploidization. Demidov D, et al. Plant J, 2014 Nov. PMID 25146886
    4. Identification and dynamics of two classes of aurora-like kinases in Arabidopsis and other plants. Demidov D, et al. Plant Cell, 2005 Mar. PMID 15722465, Free PMC Article
    5. TPX2-LIKE PROTEIN3 Is the Primary Activator of α-Aurora Kinases and Is Essential for Embryogenesis. Boruc J, et al. Plant Physiol, 2019 Jul. PMID 31097675, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TPX2-LIKE PROTEIN3 Is the Primary Activator of alpha-Aurora Kinases and Is Essential for Embryogenesis.
      Title: TPX2-LIKE PROTEIN3 Is the Primary Activator of α-Aurora Kinases and Is Essential for Embryogenesis.
    2. protein phosphorylation and substrate binding, but not protein dimerization and ubiquitination, are critical for the biological function of AtAUR2.
      Title: The α-Aurora Kinases Function in Vascular Development in Arabidopsis.
    3. Aurora kinases play an essential role in the monitoring of meiosis in plants.
      Title: Altered expression of Aurora kinases in Arabidopsis results in aneu- and polyploidization.
    4. a central role for AUR2 kinase in regulating formative division plane orientation throughout development
      Title: Arabidopsis α Aurora kinases function in formative cell division plane orientation.
    5. Aurora kinase AtAUR2 localized at the nuclear membrane in interphase and located in mitotic spindles during cell division.
      Title: Characterization of plant Aurora kinases during mitosis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    NM_001124914.1
    NM_001336028.1
    NM_128148.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone H3S10 kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in post-translational protein modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ataurora2
    NP_001118386.1
    • ataurora2 (AUR2); CONTAINS InterPro DOMAIN/s: Spindle assembly checkpoint kinase (InterPro:IPR020663), Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: ataurora1 (TAIR:AT4G32830.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_180159.2
    • ataurora2 (AUR2); CONTAINS InterPro DOMAIN/s: Spindle assembly checkpoint kinase (InterPro:IPR020663), Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: ataurora1 (TAIR:AT4G32830.1); Has 130749 Blast hits to 128519 proteins in 4314 species: Archae - 145; Bacteria - 15305; Metazoa - 47836; Fungi - 12919; Plants - 32506; Viruses - 547; Other Eukaryotes - 21491 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11034652..11038191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336027.1 → NP_001325078.1  ataurora2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B232
      Conserved Domains (1) summary
      cd14007
      Location:85 → 338
      STKc_Aurora; Catalytic domain of the Serine/Threonine kinase, Aurora kinase

    2. NM_128148.4 → NP_180159.2  ataurora2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180159.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82309, Q683C9
      UniProtKB/TrEMBL
      A0A178VY38, A0A5S9X177
      Conserved Domains (1) summary
      cd14007
      Location:24 → 277
      STKc_Aurora; Catalytic domain of the Serine/Threonine kinase, Aurora kinase

    3. NM_001336028.1 → NP_001325077.1  ataurora2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82309, Q683C9
      UniProtKB/TrEMBL
      A0A1P8B224

    4. NM_001124914.1 → NP_001118386.1  ataurora2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118386.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1IKU5, F4ITJ0
      Conserved Domains (2) summary
      smart00220
      Location:25 → 244
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14007
      Location:24 → 245
      STKc_Aurora; Catalytic domain of the Serine/Threonine kinase, Aurora kinase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools