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    CIPK3 CBL-interacting protein kinase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817240, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CIPK3
    Official Full Name
    CBL-interacting protein kinase 3
    Primary source
    TAIR:AT2G26980
    Locus tag
    AT2G26980
    See related
    Araport:AT2G26980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CBL-interacting protein kinase 3; CBL-INTERACTING PROTEIN KINASE 3; SNF1-RELATED PROTEIN KINASE 3.17; SnRK3.17; T20P8.3; T20P8_3
    Summary
    encodes a serine-threonine protein kinase whose expression increases in response to abscisic acid, cold, drought, high salt, and wounding conditions. The gene is expressed in developing seeds and seedlings. Lines carrying a T-DNA insertions have reduced germination efficiency and expression of cold, high-salt, and abscisic acid marker genes are altered, but not drought-response markers.
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    Genomic context

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    See CIPK3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Sequence:
    Chromosome: 2; NC_003071.7 (11514600..11518734, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein Neighboring gene Ctr copper transporter family Neighboring gene proteasome family protein Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis CBL interacting protein kinase 3 interacts with ABR1, an APETALA2 domain transcription factor, to regulate ABA responses. Sanyal SK, et al. Plant Sci, 2017 Jan. PMID 27964784
    2. CIPK3, a calcium sensor-associated protein kinase that regulates abscisic acid and cold signal transduction in Arabidopsis. Kim KN, et al. Plant Cell, 2003 Feb. PMID 12566581, Free PMC Article
    3. Calcineurin-B-like protein CBL9 interacts with target kinase CIPK3 in the regulation of ABA response in seed germination. Pandey GK, et al. Mol Plant, 2008 Mar. PMID 19825536
    4. Degradation of the stress-responsive enzyme formate dehydrogenase by the RING-type E3 ligase Keep on Going and the ubiquitin 26S proteasome system. McNeilly D, et al. Plant Mol Biol, 2018 Feb. PMID 29270890
    5. Tonoplast CBL-CIPK calcium signaling network regulates magnesium homeostasis in Arabidopsis. Tang RJ, et al. Proc Natl Acad Sci U S A, 2015 Mar 10. PMID 25646412, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The CBL9-CIPK3-ABR1 pathway functions to regulate seed germination and ABA dependent physiological processes in Arabidopsis.
      Title: Arabidopsis CBL interacting protein kinase 3 interacts with ABR1, an APETALA2 domain transcription factor, to regulate ABA responses.
    2. CBL9 and CIPK3 act together in the same pathway for regulating abscisic acid responses in Arabidopsis.
      Title: Calcineurin-B-like protein CBL9 interacts with target kinase CIPK3 in the regulation of ABA response in seed germination.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036350.1
    NM_001336096.1
    NM_179761.2
    NM_179763.4
    NM_179764.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in peroxisome HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    CBL-interacting protein kinase 3
    NP_001031427.1
    • CBL-interacting protein kinase 3 (CIPK3); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: Ca2+regulated serine-threonine protein kinase family protein (TAIR:AT5G21326.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001318295.1
    • CBL-interacting protein kinase 3 (CIPK3); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: Ca2+regulated serine-threonine protein kinase family protein (TAIR:AT5G21326.1); Has 131035 Blast hits to 128804 proteins in 4263 species: Archae - 194; Bacteria - 15260; Metazoa - 48258; Fungi - 13319; Plants - 31760; Viruses - 527; Other Eukaryotes - 21717 (source: NCBI BLink).
    NP_850092.1
    • CBL-interacting protein kinase 3 (CIPK3); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: Ca2+regulated serine-threonine protein kinase family protein (TAIR:AT5G21326.1); Has 131630 Blast hits to 129396 proteins in 4338 species: Archae - 194; Bacteria - 15541; Metazoa - 48417; Fungi - 13320; Plants - 31914; Viruses - 527; Other Eukaryotes - 21717 (source: NCBI BLink).
    NP_850094.1
    • CBL-interacting protein kinase 3 (CIPK3); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), CBL-interacting protein kinase (InterPro:IPR020660), NAF domain (InterPro:IPR004041), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: Ca2+regulated serine-threonine protein kinase family protein (TAIR:AT5G21326.1); Has 131082 Blast hits to 128848 proteins in 4264 species: Archae - 194; Bacteria - 15260; Metazoa - 48285; Fungi - 13319; Plants - 31784; Viruses - 527; Other Eukaryotes - 21713 (source: NCBI BLink).
    NP_850095.2
    • CBL-interacting protein kinase 3 (CIPK3); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), CBL-interacting protein kinase (InterPro:IPR020660), NAF domain (InterPro:IPR004041), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: Ca2+regulated serine-threonine protein kinase family protein (TAIR:AT5G21326.1); Has 132116 Blast hits to 129872 proteins in 4353 species: Archae - 194; Bacteria - 15566; Metazoa - 48305; Fungi - 13626; Plants - 31846; Viruses - 527; Other Eukaryotes - 22052 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11514600..11518734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179763.4 → NP_850094.1  CBL-interacting protein kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WM53, Q2V451, Q2V452, Q8RWU8, Q93VA4, Q9LKC9, Q9ZVD9
      UniProtKB/TrEMBL
      A0A178VPV9, A0A5S9X1Q1, A0A654EXP8
      Conserved Domains (3) summary
      cd12195
      Location:313 → 422
      CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases
      smart00220
      Location:14 → 269
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14663
      Location:13 → 268
      STKc_SnRK3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3

    2. NM_179764.3 → NP_850095.2  CBL-interacting protein kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850095.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VPV9, A0A5S9X1Q1, A0A654EXP8, F4IVM7
      Conserved Domains (3) summary
      cd12195
      Location:323 → 432
      CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases
      smart00220
      Location:24 → 279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14663
      Location:23 → 278
      STKc_SnRK3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3

    3. NM_001036350.1 → NP_001031427.1  CBL-interacting protein kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031427.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VPV9, A0A5S9X1Q1, A0A654EXP8, F4IVM9
      Conserved Domains (3) summary
      cd12195
      Location:313 → 392
      CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases
      smart00220
      Location:14 → 269
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14663
      Location:13 → 268
      STKc_SnRK3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3

    4. NM_179761.2 → NP_850092.1  CBL-interacting protein kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850092.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VPV9, A0A5S9X1Q1, A0A654EXP8
      Conserved Domains (3) summary
      cd12195
      Location:313 → 370
      CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases
      smart00220
      Location:14 → 269
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14663
      Location:13 → 268
      STKc_SnRK3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3

    5. NM_001336096.1 → NP_001318295.1  CBL-interacting protein kinase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VNR6, A0A178VRC5, A0A2H1ZE41, A0A384KDB5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2V452.2

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