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    Major facilitator superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819414, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Major facilitator superfamily protein
    Primary source
    TAIR:AT2G48020
    Locus tag
    AT2G48020
    See related
    Araport:AT2G48020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T9J23.17; ZIF2; Zinc-Induced Facilitator 2
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    17
    Sequence:
    Chromosome: 2; NC_003071.7 (19644021..19647365)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene receptor-like kinase in in flowers 3 Neighboring gene DNAse I-like superfamily protein Neighboring gene piezo-type mechanosensitive ion channel component Neighboring gene resistance to phytophthora 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intron retention in the 5'UTR of the novel ZIF2 transporter enhances translation to promote zinc tolerance in arabidopsis. Remy E, et al. PLoS Genet, 2014. PMID 24832541, Free PMC Article
    2. A split-ubiquitin yeast two-hybrid screen to examine the substrate specificity of atToc159 and atToc132, two Arabidopsis chloroplast preprotein import receptors. Dutta S, et al. PLoS One, 2014. PMID 24736607, Free PMC Article
    3. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
    4. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings indicate that alternative splicing controls the levels of a Zn-responsive mRNA variant of the ZIF2 transporter to enhance plant tolerance to the metal ion. [ZIF2]
      Title: Intron retention in the 5'UTR of the novel ZIF2 transporter enhances translation to promote zinc tolerance in arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001337287.1
    NM_001337288.1
    NM_130369.4
    NM_180152.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables carbohydrate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sugar transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc efflux transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within zinc ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Major facilitator superfamily protein
    NP_566120.1
    • Major facilitator superfamily protein; FUNCTIONS IN: carbohydrate transmembrane transporter activity, sugar:hydrogen symporter activity; INVOLVED IN: transport, transmembrane transport; LOCATED IN: plasma membrane, chloroplast, vacuole, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Sugar transporter, conserved site (InterPro:IPR005829), Major facilitator superfamily (InterPro:IPR020846), General substrate transporter (InterPro:IPR005828), Sugar/inositol transporter (InterPro:IPR003663), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: Major facilitator superfamily protein (TAIR:AT5G18840.1); Has 32576 Blast hits to 32035 proteins in 2204 species: Archae - 531; Bacteria - 16009; Metazoa - 5272; Fungi - 6662; Plants - 2708; Viruses - 2; Other Eukaryotes - 1392 (source: NCBI BLink).
    NP_850483.1
    • Major facilitator superfamily protein; FUNCTIONS IN: carbohydrate transmembrane transporter activity, sugar:hydrogen symporter activity; INVOLVED IN: transport, transmembrane transport; LOCATED IN: plasma membrane, chloroplast, vacuole, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Sugar transporter, conserved site (InterPro:IPR005829), Major facilitator superfamily (InterPro:IPR020846), General substrate transporter (InterPro:IPR005828), Sugar/inositol transporter (InterPro:IPR003663), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: Major facilitator superfamily protein (TAIR:AT5G18840.1); Has 32576 Blast hits to 32035 proteins in 2204 species: Archae - 531; Bacteria - 16009; Metazoa - 5272; Fungi - 6662; Plants - 2708; Viruses - 2; Other Eukaryotes - 1392 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19644021..19647365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180152.3 → NP_850483.1  Major facilitator superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850483.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P93051, Q8LFR8, Q9ZU87
      UniProtKB/TrEMBL
      A0A178VT61, A0A5S9X7Z2
      Conserved Domains (1) summary
      cd17358
      Location:29 → 456
      MFS_GLUT6_8_Class3_like; Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily

    2. NM_130369.4 → NP_566120.1  Major facilitator superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566120.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P93051, Q8LFR8, Q9ZU87
      UniProtKB/TrEMBL
      A0A178VT61, A0A5S9X7Z2
      Conserved Domains (1) summary
      cd17358
      Location:29 → 456
      MFS_GLUT6_8_Class3_like; Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily

    3. NM_001337287.1 → NP_001324069.1  Major facilitator superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZ27

    4. NM_001337288.1 → NP_001324070.1  Major facilitator superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZ00
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P93051.2

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