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    UPS2 ureide permease 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814882, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UPS2
    Official Full Name
    ureide permease 2
    Primary source
    TAIR:AT2G03530
    Locus tag
    AT2G03530
    See related
    Araport:AT2G03530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA UREIDE PERMEASE 2; ATUPS2; T4M8.3; T4M8_3; ureide permease 2
    Summary
    Mediate high-affinity uracil and 5-FU (a toxic uracil analogue) transport when expressed in yeast and Xenopus oocytes.Involved in allantoin transport.
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    Genomic context

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    See UPS2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (1071453..1074016)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene SPFH/Band 7/PHB domain-containing membrane-associated protein family Neighboring gene ureide permease 4 Neighboring gene pseudo Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene F-box only protein (DUF295)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UPS1 and UPS2 from Arabidopsis mediate high affinity transport of uracil and 5-fluorouracil. Schmidt A, et al. J Biol Chem, 2004 Oct 22. PMID 15308648
    2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UPS1 and UPS2 from Arabidopsis have roles in high affinity transport of uracil and 5-fluorouracil [UPS2]
      Title: UPS1 and UPS2 from Arabidopsis mediate high affinity transport of uracil and 5-fluorouracil.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001084405.2
    NM_001335188.1
    NM_001335189.1
    NM_001335190.1
    NM_126403.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables allantoin:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uracil transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uracil:monoatomic cation symporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in allantoin transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyrimidine nucleobase salvage TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in uracil transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ureide permease 2
    NP_001077874.1
    • ureide permease 2 (UPS2); FUNCTIONS IN: uracil:cation symporter activity; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 10 growth stages; BEST Arabidopsis thaliana protein match is: ureide permease 1 (TAIR:AT2G03590.1); Has 297 Blast hits to 263 proteins in 72 species: Archae - 0; Bacteria - 145; Metazoa - 0; Fungi - 0; Plants - 118; Viruses - 0; Other Eukaryotes - 34 (source: NCBI BLink).
    NP_178451.2
    • ureide permease 2 (UPS2); FUNCTIONS IN: uracil:cation symporter activity; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 10 growth stages; BEST Arabidopsis thaliana protein match is: ureide permease 1 (TAIR:AT2G03590.1); Has 297 Blast hits to 263 proteins in 72 species: Archae - 0; Bacteria - 145; Metazoa - 0; Fungi - 0; Plants - 118; Viruses - 0; Other Eukaryotes - 34 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      1071453..1074016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126403.4 → NP_178451.2  ureide permease 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178451.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZQ89
      UniProtKB/TrEMBL
      A0A178VPJ5
      Conserved Domains (1) summary
      pfam07168
      Location:41 → 393
      Ureide_permease; Ureide permease

    2. NM_001335188.1 → NP_001324121.1  ureide permease 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZ26
      Conserved Domains (1) summary
      pfam07168
      Location:1 → 308
      Ureide_permease; Ureide permease

    3. NM_001335189.1 → NP_001324119.1  ureide permease 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VPW1, A0A1P8AZ74

    4. NM_001335190.1 → NP_001324120.1  ureide permease 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZ26
      Conserved Domains (1) summary
      pfam07168
      Location:1 → 308
      Ureide_permease; Ureide permease

    5. NM_001084405.2 → NP_001077874.1  ureide permease 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077874.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZQ89
      UniProtKB/TrEMBL
      A0A178VPJ5
      Conserved Domains (1) summary
      pfam07168
      Location:41 → 393
      Ureide_permease; Ureide permease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZQ89.2

    Gene LinkOut

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