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    STY8 ACT-like protein tyrosine kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816278, updated on 18-Sep-2024

    Summary

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    Official Symbol
    STY8
    Official Full Name
    ACT-like protein tyrosine kinase family protein
    Primary source
    TAIR:AT2G17700
    Locus tag
    AT2G17700
    See related
    Araport:AT2G17700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    serine/threonine/tyrosine kinase 8; T17A5.2; T17A5_2
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    Genomic context

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    See STY8 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    15
    Sequence:
    Chromosome: 2; NC_003071.7 (7685354..7689445, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene DUF241 domain protein, putative (DUF241) Neighboring gene outer envelope protein Neighboring gene ascorbic acid mannose pathway regulator, putative (DUF295) Neighboring gene methionine-S-oxide reductase Neighboring gene Big1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ACT domain in chloroplast precursor-phosphorylating STY kinases binds metabolites and allosterically regulates kinase activity. Eisa A, et al. J Biol Chem, 2019 Nov 15. PMID 31594863, Free PMC Article
    2. The cytosolic kinases STY8, STY17, and STY46 are involved in chloroplast differentiation in Arabidopsis. Lamberti G, et al. Plant Physiol, 2011 Sep. PMID 21799034, Free PMC Article
    3. A protein kinase family in Arabidopsis phosphorylates chloroplast precursor proteins. Martin T, et al. J Biol Chem, 2006 Dec 29. PMID 17090544
    4. The Raf-like MAPKKKs STY8, STY17, and STY46 negatively regulate Botrytis cinerea resistance by limiting MKK7 protein accumulation in Arabidopsis. Chen L, et al. Plant J, 2024 Mar. PMID 38059690
    5. Genome-wide analysis and experimentation of plant serine/ threonine/tyrosine-specific protein kinases. Rudrabhatla P, et al. Plant Mol Biol, 2006 Jan. PMID 16429265

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ACT domain in chloroplast precursor-phosphorylating STY8, STY17, and STY46 kinases regulates activity and substrate binding.
      Title: The ACT domain in chloroplast precursor-phosphorylating STY kinases binds metabolites and allosterically regulates kinase activity.
    2. The protein kinase AT2G17700 could represent a subunit of a regulatory network involved in the cytosolic events of chloroplast protein import.
      Title: A protein kinase family in Arabidopsis phosphorylates chloroplast precursor proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_127324.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine/tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ACT-like protein tyrosine kinase family protein
    NP_179361.1
    • ACT-like protein tyrosine kinase family protein; FUNCTIONS IN: protein serine/threonine/tyrosine kinase activity, protein kinase activity; INVOLVED IN: protein amino acid phosphorylation, metabolic process; LOCATED IN: cytosol; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Amino acid-binding ACT (InterPro:IPR002912), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Serine/threonine protein kinase-like, ATMRK (InterPro:IPR015783), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: ACT-like protein tyrosine kinase family protein (TAIR:AT4G35780.1); Has 131925 Blast hits to 129768 proteins in 5057 species: Archae - 139; Bacteria - 14109; Metazoa - 50800; Fungi - 11992; Plants - 33819; Viruses - 503; Other Eukaryotes - 20563 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7685354..7689445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127324.5 → NP_179361.1  ACT-like protein tyrosine kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179361.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22558, Q56XF0
      UniProtKB/TrEMBL
      A0A178VMP6
      Conserved Domains (3) summary
      cd04928
      Location:172 → 239
      ACT_TyrKc; Uncharacterized, N-terminal ACT domain of an Arabidopsis/Oryza predicted tyrosine kinase and other related ACT domains
      cd13999
      Location:292 → 535
      STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases
      pfam07714
      Location:286 → 535
      Pkinase_Tyr; Protein tyrosine kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22558.2

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