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    AGT alanine:glyoxylate aminotransferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815822, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AGT
    Official Full Name
    alanine:glyoxylate aminotransferase
    Primary source
    TAIR:AT2G13360
    Locus tag
    AT2G13360
    See related
    Araport:AT2G13360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGT1; alanine:glyoxylate aminotransferase; ALANINE:GLYOXYLATE AMINOTRANSFERASE; ALANINE:GLYOXYLATE AMINOTRANSFERASE 1; F14O4.7; F14O4_7; L-serine:glyoxylate aminotransferase; SGAT
    Summary
    Encodes a peroxisomal photorespiratory enzyme that catalyzes transamination reactions with multiple substrates. It is involved in photorespiration.
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    Genomic context

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    See AGT in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (5538740..5541479, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene chromatin remodeling 5 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Arabidopsis serine:glyoxylate aminotransferase, AGT1, as an asparagine aminotransferase. Zhang Q, et al. Phytochemistry, 2013 Jan. PMID 23098902
    2. Peroxisomal alanine : glyoxylate aminotransferase (AGT1) is a photorespiratory enzyme with multiple substrates in Arabidopsis thaliana. Liepman AH, et al. Plant J, 2001 Mar. PMID 11309139
    3. Identification and characterization of omega-amidase as an enzyme metabolically linked to asparagine transamination in Arabidopsis. Zhang Q, et al. Phytochemistry, 2014 Mar. PMID 24461228
    4. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
    5. VH1/BRL2 receptor-like kinase interacts with vascular-specific adaptor proteins VIT and VIK to influence leaf venation. Ceserani T, et al. Plant J, 2009 Mar. PMID 19000166, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the enzyme serine:glyoxylate aminotransferase encoded by AGT1 has been identified as an asparagine aminotransferase in Arabidopsis
      Title: Identification and characterization of omega-amidase as an enzyme metabolically linked to asparagine transamination in Arabidopsis.
    2. The results suggest that AGT1 is involved in Asn metabolism in Arabidopsis.
      Title: Characterization of Arabidopsis serine:glyoxylate aminotransferase, AGT1, as an asparagine aminotransferase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001335388.1
    NM_126925.5
    NM_179620.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-serine-glyoxylate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-serine-pyruvate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alanine-glyoxylate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within photorespiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in peroxisome HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    alanine:glyoxylate aminotransferase
    NP_001318216.1
    • alanine:glyoxylate aminotransferase (AGT); FUNCTIONS IN: serine-pyruvate transaminase activity, serine-glyoxylate transaminase activity, alanine-glyoxylate transaminase activity; INVOLVED IN: photorespiration; LOCATED IN: in 6 components; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase, class V/Cysteine desulfurase (InterPro:IPR000192), Aminotransferase class-V pyridoxal-phosphate binding site (InterPro:IPR020578), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); Has 6407 Blast hits to 6405 proteins in 1610 species: Archae - 309; Bacteria - 3905; Metazoa - 186; Fungi - 125; Plants - 148; Viruses - 0; Other Eukaryotes - 1734 (source: NCBI BLink).
    NP_849951.1
    • alanine:glyoxylate aminotransferase (AGT); FUNCTIONS IN: serine-pyruvate transaminase activity, serine-glyoxylate transaminase activity, alanine-glyoxylate transaminase activity; INVOLVED IN: photorespiration; LOCATED IN: apoplast, peroxisome, plasma membrane, chloroplast, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase, class V/Cysteine desulfurase (InterPro:IPR000192), Aminotransferase class-V pyridoxal-phosphate binding site (InterPro:IPR020578), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); Has 6407 Blast hits to 6405 proteins in 1610 species: Archae - 309; Bacteria - 3905; Metazoa - 186; Fungi - 125; Plants - 148; Viruses - 0; Other Eukaryotes - 1734 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      5538740..5541479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335388.1 → NP_001318216.1  alanine:glyoxylate aminotransferase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81248, Q56YA5
      UniProtKB/TrEMBL
      A0A178VX39, A0A5S9XHQ3, A0A7G2EC25
      Conserved Domains (1) summary
      PLN02409
      Location:1 → 401
      PLN02409; serine--glyoxylate aminotransaminase

    2. NM_126925.5 → NP_178969.1  alanine:glyoxylate aminotransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178969.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81248, Q56YA5
      UniProtKB/TrEMBL
      A0A178VX39, A0A5S9XHQ3, A0A7G2EC25
      Conserved Domains (1) summary
      PLN02409
      Location:1 → 401
      PLN02409; serine--glyoxylate aminotransaminase

    3. NM_179620.2 → NP_849951.1  alanine:glyoxylate aminotransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849951.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81248, Q56YA5
      UniProtKB/TrEMBL
      A0A178VX39, A0A5S9XHQ3, A0A7G2EC25
      Conserved Domains (1) summary
      PLN02409
      Location:1 → 401
      PLN02409; serine--glyoxylate aminotransaminase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q56YA5.2

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