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    ARR4 response regulator 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837587, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARR4
    Official Full Name
    response regulator 4
    Primary source
    TAIR:AT1G10470
    Locus tag
    AT1G10470
    See related
    Araport:AT1G10470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRR1; IBC7; INDUCED BY CYTOKININ 7; maternal effect embryo arrest 7; MEE7; RESPONCE REGULATOR 1; response regulator 4; T10O24.8; T10O24_8
    Summary
    Encodes a two-component response regulator. Acts redundantly with ARR3 in the control of circadian period in a cytokinin-independent manner.
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    Genomic context

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    See ARR4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (3441988..3444360, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene B3 DNA-binding domain protein Neighboring gene germin-like protein 7 Neighboring gene zinc finger protein 5 Neighboring gene GNAT acetyltransferase (DUF699) Neighboring gene chloroplast-localized ISCA-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DEG9, a serine protease, modulates cytokinin and light signaling by regulating the level of ARABIDOPSIS RESPONSE REGULATOR 4. Chi W, et al. Proc Natl Acad Sci U S A, 2016 Jun 21. PMID 27274065, Free PMC Article
    2. EXO70D isoforms mediate selective autophagic degradation of type-A ARR proteins to regulate cytokinin sensitivity. Acheampong AK, et al. Proc Natl Acad Sci U S A, 2020 Oct 27. PMID 33051300, Free PMC Article
    3. Two genes with similarity to bacterial response regulators are rapidly and specifically induced by cytokinin in Arabidopsis. Brandstatter I, et al. Plant Cell, 1998 Jun. PMID 9634588, Free PMC Article
    4. Interaction of the response regulator ARR4 with phytochrome B in modulating red light signaling. Sweere U, et al. Science, 2001 Nov 2. PMID 11691995
    5. Stress-responsive expression of genes for two-component response regulator-like proteins in Arabidopsis thaliana. Urao T, et al. FEBS Lett, 1998 May 8. PMID 9607306

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EXO70D isoforms mediate selective autophagic degradation of type-A ARR proteins to regulate cytokinin sensitivity.
      Title: EXO70D isoforms mediate selective autophagic degradation of type-A ARR proteins to regulate cytokinin sensitivity.
    2. genetic evidence shows that DEG9 acts upstream of ARR4 and regulates the activity of ARR4 in cytokinin and light-signaling pathways
      Title: DEG9, a serine protease, modulates cytokinin and light signaling by regulating the level of ARABIDOPSIS RESPONSE REGULATOR 4.
    3. Mutating selected interface residues of ARR4 either abolished or destabilized the interaction. D45A and Y96A mutations weakened interaction with AHP1, and exhibited weaker rescue of root elongation in the hextuple mutants.
      Title: Destabilization of interaction between cytokinin signaling intermediates AHP1 and ARR4 modulates Arabidopsis development.
    4. Cross-talk between cytokinin and light signalling is mediated by ARR4.
      Title: Functional cross-talk between two-component and phytochrome B signal transduction in Arabidopsis.
    5. Results suggest that ARR3 and ARR4 are critical for proper circadian period and define an additional level of regulation of the circadian clock in Arabidopsis.
      Title: Arabidopsis response regulators ARR3 and ARR4 play cytokinin-independent roles in the control of circadian period.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001331908.1
    NM_001331909.1
    NM_100921.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphorelay response regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphorelay response regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytokinin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytokinin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinin-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    acts_upstream_of_or_within red or far-red light signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of circadian rhythm IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    response regulator 4
    NP_172517.1
    • response regulator 4 (ARR4); CONTAINS InterPro DOMAIN/s: CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789); BEST Arabidopsis thaliana protein match is: response regulator 3 (TAIR:AT1G59940.1); Has 56806 Blast hits to 56102 proteins in 2778 species: Archae - 292; Bacteria - 49762; Metazoa - 41; Fungi - 583; Plants - 1526; Viruses - 7; Other Eukaryotes - 4595 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3441988..3444360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100921.3 → NP_172517.1  response regulator 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172517.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82798
      UniProtKB/TrEMBL
      A0A178WJ74, A0A384KIL5, A0A7G2DRR3, Q2HIV3
      Conserved Domains (1) summary
      cd17581
      Location:36 → 157
      REC_typeA_ARR; phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and similar proteins

    2. NM_001331909.1 → NP_001321924.1  response regulator 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASD9, A0A7G2DRR3

    3. NM_001331908.1 → NP_001321923.1  response regulator 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASI6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82798.1

    Gene LinkOut

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