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    GAMMA-ADAPTIN 1 gamma-adaptin 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839001, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GAMMA-ADAPTIN 1
    Official Full Name
    gamma-adaptin 1
    Primary source
    TAIR:AT1G23900
    Locus tag
    AT1G23900
    See related
    Araport:AT1G23900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Gamma-adaptin; gamma-adaptin 1; Gamma-ADR
    Summary
    Encodes large subunit of the heterotetrameric adaptor protein complex AP-1. AP-1 is required for clathrin coated vesicles budding from the trans-Golgi network or plasma membrane
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    Genomic context

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    See GAMMA-ADAPTIN 1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Sequence:
    Chromosome: 1; NC_003070.9 (8441073..8447681)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene trehalose-phosphatase/synthase 9 Neighboring gene NHL domain-containing protein Neighboring gene NHL domain-containing protein Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic analysis of components of the eukaryotic vesicle transport system reveals a common origin of adaptor protein complexes 1, 2, and 3 and the F subcomplex of the coatomer COPI. Schledzewski K, et al. J Mol Evol, 1999 Jun. PMID 10229581
    2. Arabidopsis μ-adaptin subunit AP1M of adaptor protein complex 1 mediates late secretory and vacuolar traffic and is required for growth. Park M, et al. Proc Natl Acad Sci U S A, 2013 Jun 18. PMID 23733933, Free PMC Article
    3. Regulation of ADL6 activity by its associated molecular network. Lam BC, et al. Plant J, 2002 Sep. PMID 12207647
    4. Trans-Golgi network-located AP1 gamma adaptins mediate dileucine motif-directed vacuolar targeting in Arabidopsis. Wang X, et al. Plant Cell, 2014 Oct. PMID 25351491, Free PMC Article
    5. Arabidopsis EPSIN1 plays an important role in vacuolar trafficking of soluble cargo proteins in plant cells via interactions with clathrin, AP-1, VTI11, and VSR1. Song J, et al. Plant Cell, 2006 Sep. PMID 16905657, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_102238.2
    NM_179370.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of AP-1 adaptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    gamma-adaptin 1
    NP_173802.1
    • gamma-adaptin 1 (GAMMA-ADAPTIN 1); FUNCTIONS IN: protein transporter activity, clathrin binding, binding; INVOLVED IN: vesicle-mediated transport; LOCATED IN: AP-1 adaptor complex; CONTAINS InterPro DOMAIN/s: Adaptor protein complex AP-1, gamma subunit (InterPro:IPR017107), Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (InterPro:IPR008152), Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024), Clathrin adaptor, gamma-adaptin, appendage (InterPro:IPR008153), Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain (InterPro:IPR013041), Clathrin/coatomer adaptor, adaptin-like, N-terminal (InterPro:IPR002553); BEST Arabidopsis thaliana protein match is: Adaptor protein complex AP-1, gamma subunit (TAIR:AT1G60070.1); Has 3543 Blast hits to 3448 proteins in 308 species: Archae - 0; Bacteria - 4; Metazoa - 1517; Fungi - 967; Plants - 387; Viruses - 0; Other Eukaryotes - 668 (source: NCBI BLink).
    NP_849701.1
    • gamma-adaptin 1 (GAMMA-ADAPTIN 1); FUNCTIONS IN: protein transporter activity, clathrin binding, binding; INVOLVED IN: vesicle-mediated transport; LOCATED IN: AP-1 adaptor complex; CONTAINS InterPro DOMAIN/s: Adaptor protein complex AP-1, gamma subunit (InterPro:IPR017107), Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (InterPro:IPR008152), Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024), Clathrin adaptor, gamma-adaptin, appendage (InterPro:IPR008153), Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain (InterPro:IPR013041), Clathrin/coatomer adaptor, adaptin-like, N-terminal (InterPro:IPR002553); BEST Arabidopsis thaliana protein match is: Adaptor protein complex AP-1, gamma subunit (TAIR:AT1G60070.1); Has 3543 Blast hits to 3448 proteins in 308 species: Archae - 0; Bacteria - 4; Metazoa - 1517; Fungi - 967; Plants - 387; Viruses - 0; Other Eukaryotes - 668 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8441073..8447681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332624.1 → NP_001322140.1  gamma-adaptin 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WHX1, A0A1P8AT76

    2. NM_179370.4 → NP_849701.1  gamma-adaptin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849701.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81227, Q84K16, Q9LRA3, Q9XFS0
      UniProtKB/TrEMBL
      A0A178WHX1
      Conserved Domains (5) summary
      smart00809
      Location:763 → 873
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:26 → 580
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:317 → 450
      Cnd1; non-SMC mitotic condensation complex subunit 1
      pfam14796
      Location:718 → 801
      AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
      sd00044
      Location:314 → 338
      HEAT; HEAT repeat [structural motif]

    3. NM_102238.2 → NP_173802.1  gamma-adaptin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173802.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81227, Q84K16, Q9LRA3, Q9XFS0
      UniProtKB/TrEMBL
      A0A178WHX1
      Conserved Domains (5) summary
      smart00809
      Location:763 → 873
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:26 → 580
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:317 → 450
      Cnd1; non-SMC mitotic condensation complex subunit 1
      pfam14796
      Location:718 → 801
      AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
      sd00044
      Location:314 → 338
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84K16.1

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