SS3 starch synthase 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SS3
Official Full Name: starch synthase 3
Primary source: TAIR:AT1G11720
Locus tag: AT1G11720
See related: Araport:AT1G11720
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATSS3; F25C20.13; F25C20_13; starch synthase 3; STARCH SYNTHASE III
Summary: Encodes a starch synthase that in addition to its role in starch biosynthesis also has a negative regulatory function in the biosynthesis of transient starch. The protein apparently contains a starch-binding domain (SBD).
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Genomic context

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See SS3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 16

Sequence:: Chromosome: 1; NC_003070.9 (3951366..3957044)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

interaction of N-terminal starch-binding domains, particularly the D(316-344) and D(495-535) regions, with the catalytic domains, as well as the full integrity of the starch-binding capacity of the D2 domain, are involved in starch synthase III activity
Title: The starch-binding capacity of the noncatalytic SBD2 region and the interaction between the N- and C-terminal domains are involved in the modulation of the activity of starch synthase III from Arabidopsis thaliana.
The data point to a complex mechanism for starch granule formation and to the different abilities of SSIV and SSIII to support this process in Arabidopsis leaves.
Title: Starch granule initiation in Arabidopsis requires the presence of either class IV or class III starch synthases.
SSII and SSIII have partially redundant functions. Loss of SSII caused increased amylose/amylopectin ratio, and loss of both SSII and SSIII caused slower plant growth and reduced starch content.
Title: Overlapping functions of the starch synthases SSII and SSIII in amylopectin biosynthesis in Arabidopsis.
Results presented here suggest that the N-terminal SBDs have a regulatory role, showing a starch binding capacity and modulating the catalytic properties of SSIII.
Title: Role of the N-terminal starch-binding domains in the kinetic properties of starch synthase III from Arabidopsis thaliana.
starch-synthase III (SSIII) contains a putative N-terminal transit peptide followed by a 557-amino acid SSIII-specific domain with 3 internal repeats & a C-terminal catalytic domain; each of the 3 internal repeats encodes a starch-binding domain
Title: Starch-synthase III family encodes a tandem of three starch-binding domains.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001198036.2

Supported by ESTs:

NM_101044.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables alpha-1,4-glucan glucosyltransferase (ADP-glucose donor) activity	IEA Inferred from Electronic Annotation more info
enables alpha-1,4-glucan glucosyltransferase (ADP-glucose donor) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity	IEA Inferred from Electronic Annotation more info
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables starch binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amylopectin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in starch biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within starch biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: starch synthase 3

NP_001184965.1

starch synthase 3 (SS3); CONTAINS InterPro DOMAIN/s: Glycogen/starch synthases, ADP-glucose type (InterPro:IPR011835), Starch synthase, catalytic domain (InterPro:IPR013534), Glycosyl transferase, group 1 (InterPro:IPR001296), Carbohydrate binding domain, family 25 (InterPro:IPR005085); BEST Arabidopsis thaliana protein match is: starch synthase 4 (TAIR:AT4G18240.1).

NP_172637.2

starch synthase 3 (SS3); FUNCTIONS IN: starch synthase activity, transferase activity, transferring glycosyl groups; INVOLVED IN: starch biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glycogen/starch synthases, ADP-glucose type (InterPro:IPR011835), Starch synthase, catalytic domain (InterPro:IPR013534), Glycosyl transferase, group 1 (InterPro:IPR001296), Carbohydrate binding domain, family 25 (InterPro:IPR005085); BEST Arabidopsis thaliana protein match is: starch synthase 4 (TAIR:AT4G18240.1); Has 8453 Blast hits to 8330 proteins in 2963 species: Archae - 164; Bacteria - 3762; Metazoa - 19; Fungi - 103; Plants - 3720; Viruses - 1; Other Eukaryotes - 684 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

3951366..3957044

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001198036.2 → NP_001184965.1 starch synthase 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001184965.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W4M9, A0A5S9TWT2, F4IAG1

Conserved Domains (1) summary

PLN02316
Location:70 → 1094

PLN02316; synthase/transferase
NM_101044.3 → NP_172637.2 starch synthase 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172637.2

Status: REVIEWED

UniProtKB/Swiss-Prot

F4IAG2, Q1WAB7, Q306T0, Q9SAA5

UniProtKB/TrEMBL

A0A654E8W2

Conserved Domains (4) summary

cd03791
Location:595 → 1039

GT1_Glycogen_synthase_DULL1_like; This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family ...

PLN02316
Location:18 → 1042

PLN02316; synthase/transferase

pfam12824
Location:254 → 302

MRP-L20; Mitochondrial ribosomal protein subunit L20

pfam16760
Location:498 → 587

CBM53; Starch/carbohydrate-binding module (family 53)