ELF5A-1 eukaryotic elongation factor 5A-1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ELF5A-1
Official Full Name: eukaryotic elongation factor 5A-1
Primary source: TAIR:AT1G13950
Locus tag: AT1G13950
See related: Araport:AT1G13950
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATELF5A-1; EIF-5A; EIF5A; EUKARYOTIC ELONGATION FACTOR 5A; eukaryotic elongation factor 5A-1; EUKARYOTIC ELONGATION FACTOR 5A-1; F16A14.17
Summary: Encodes eukaryotic translation initiation factor 5A (EIF-5A).In mammalian cells it functions as a shuttle protein that translocates mRNA from the nucleus to cytoplasmic ribosomes. Overexpression results in an increase in both primary and secondary xylem formation. In RNAi suppressed lines, xylem formation is reduced.
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Genomic context

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See ELF5A-1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 5

Sequence:: Chromosome: 1; NC_003070.9 (4773434..4774935)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A study evaluating the role of eIF5A1 in xylem formation is presented.
Title: Modulation of eIF5A1 expression alters xylem abundance in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_101261.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of translational elongation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational termination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within xylem development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in extracellular region	HDA more info	PubMed

General protein information

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Preferred Names: eukaryotic elongation factor 5A-1

NP_172848.1

eukaryotic elongation factor 5A-1 (ELF5A-1); FUNCTIONS IN: ribosome binding, RNA binding, translation elongation factor activity, translation initiation factor activity; INVOLVED IN: translational initiation, xylem development; LOCATED IN: cellular_component unknown; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold (InterPro:IPR012340), Translation elongation factor, IF5A, hypusine site (InterPro:IPR019769), Translation protein SH3-like, subgroup (InterPro:IPR014722), Translation elongation factor, IF5A (InterPro:IPR001884), Translation elongation factor, IF5A C-terminal (InterPro:IPR020189), Translation protein SH3-like (InterPro:IPR008991), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), KOW (InterPro:IPR005824); BEST Arabidopsis thaliana protein match is: eukaryotic elongation factor 5A-3 (TAIR:AT1G69410.1); Has 1356 Blast hits to 1355 proteins in 415 species: Archae - 264; Bacteria - 0; Metazoa - 366; Fungi - 246; Plants - 261; Viruses - 0; Other Eukaryotes - 219 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

4773434..4774935

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101261.3 → NP_172848.1 eukaryotic elongation factor 5A-1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172848.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LMG2, Q9XI91

UniProtKB/TrEMBL

A0A178WBN7, A0A5S9UAB4

Conserved Domains (1) summary

PLN03107
Location:1 → 158

PLN03107; eukaryotic translation initiation factor 5A; Provisional