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    TOPP3 type one serine/threonine protein phosphatase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842708, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TOPP3
    Official Full Name
    type one serine/threonine protein phosphatase 3
    Primary source
    TAIR:AT1G64040
    Locus tag
    AT1G64040
    See related
    Araport:AT1G64040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    type one serine/threonine protein phosphatase 3
    Summary
    Encodes the catalytic subunit of a Type 1 phosphoprotein Ser/Thr phosphatase, expressed in roots, shoots and flowers.
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    Genomic context

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    See TOPP3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (23758241..23760663, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene serpin 3 Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene respiratory burst oxidase protein F

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of multiple type 1 phosphoprotein phosphatases in Arabidopsis thaliana. Smith RD, et al. Plant Mol Biol, 1993 Jan. PMID 7678768
    2. Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit. Templeton GW, et al. Biochem J, 2011 Apr 1. PMID 21222654
    3. Identification and functional characterization of inhibitor-3, a regulatory subunit of protein phosphatase 1 in plants. Takemiya A, et al. Plant Physiol, 2009 May. PMID 19329567, Free PMC Article
    4. High-throughput protein localization in Arabidopsis using Agrobacterium-mediated transient expression of GFP-ORF fusions. Koroleva OA, et al. Plant J, 2005 Jan. PMID 15610358
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_105077.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein dephosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    part_of protein phosphatase type 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type one serine/threonine protein phosphatase 3
    NP_176587.1
    • type one serine/threonine protein phosphatase 3 (TOPP3); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: Calcineurin-like metallo-phosphoesterase superfamily protein (TAIR:AT4G11240.1); Has 6826 Blast hits to 6627 proteins in 481 species: Archae - 78; Bacteria - 203; Metazoa - 2409; Fungi - 1417; Plants - 984; Viruses - 0; Other Eukaryotes - 1735 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      23758241..23760663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105077.4 → NP_176587.1  type one serine/threonine protein phosphatase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176587.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48483, Q9SH54
      UniProtKB/TrEMBL
      A0A178WMA0, A0A5S9WPK3, A0A654EKS6
      Conserved Domains (1) summary
      cd07414
      Location:5 → 294
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48483.1

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