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    DWA2 DWD (DDB1-binding WD40 protein) hypersensitive to ABA 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843959, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DWA2
    Official Full Name
    DWD (DDB1-binding WD40 protein) hypersensitive to ABA 2
    Primary source
    TAIR:AT1G76260
    Locus tag
    AT1G76260
    See related
    Araport:AT1G76260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DWD (DDB1-binding WD40 protein) hypersensitive to ABA 2; T23E18.19; T23E18_19
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    Genomic context

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    See DWA2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (28610193..28613263)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene DUF241 domain protein (DUF241) Neighboring gene uncharacterized protein Neighboring gene O-fucosyltransferase family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene AMP-dependent synthetase and ligase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DWA1 and DWA2, two Arabidopsis DWD protein components of CUL4-based E3 ligases, act together as negative regulators in ABA signal transduction. Lee JH, et al. Plant Cell, 2010 Jun. PMID 20525848, Free PMC Article
    2. Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Lee JH, et al. Plant Cell, 2008 Jan. PMID 18223036, Free PMC Article
    3. Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. Zhang Y, et al. Plant Cell, 2008 Jun. PMID 18552200, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DWA1 and DWA2 interact with DDB1 and ABI5 to negatively regulate abscisic acid signal transduction.
      Title: DWA1 and DWA2, two Arabidopsis DWD protein components of CUL4-based E3 ligases, act together as negative regulators in ABA signal transduction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_106276.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DWD (DDB1-binding WD40 protein) hypersensitive to ABA 2
    NP_177753.1
    • DWD (DDB1-binding WD40 protein) hypersensitive to ABA 2 (DWA2); CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40 repeat (InterPro:IPR001680), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT1G20540.1); Has 7905 Blast hits to 6688 proteins in 412 species: Archae - 0; Bacteria - 764; Metazoa - 3555; Fungi - 1654; Plants - 1112; Viruses - 0; Other Eukaryotes - 820 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28610193..28613263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106276.5 → NP_177753.1  DWD (DDB1-binding WD40 protein) hypersensitive to ABA 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177753.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q67YQ8, Q6NPN9, Q9SFW2, Q9SGQ8
      UniProtKB/TrEMBL
      A0A178WGV4, A0A5S9WUT7, A0A654EPP3
      Conserved Domains (2) summary
      COG2319
      Location:51 → 344
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:19 → 63
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NPN9.1

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