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    LOX3 lipoxygenase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838314, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LOX3
    Official Full Name
    lipoxygenase 3
    Primary source
    TAIR:AT1G17420
    Locus tag
    AT1G17420
    See related
    Araport:AT1G17420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana lipoxygenase 3; ATLOX3; F28G4.10; lipoxygenase 3
    Summary
    LOX3 encode a Lipoxygenase. Lipoxygenases (LOXs) catalyze the oxygenation of fatty acids (FAs).
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    Genomic context

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    See LOX3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (5977323..5981521)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Nucleoside diphosphate kinase family protein Neighboring gene ncRNA Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene Transcription initiation factor TFIID subunit A Neighboring gene B-block binding subunit of TFIIIC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mapping methyl jasmonate-mediated transcriptional reprogramming of metabolism and cell cycle progression in cultured Arabidopsis cells. Pauwels L, et al. Proc Natl Acad Sci U S A, 2008 Jan 29. PMID 18216250, Free PMC Article
    2. Absence of endo-1,4-β-glucanase KOR1 alters the jasmonate-dependent defence response to Pseudomonas syringae in Arabidopsis. López-Cruz J, et al. J Plant Physiol, 2014 Oct 15. PMID 25108263
    3. Arabidopsis lox3 lox4 double mutants are male sterile and defective in global proliferative arrest. Caldelari D, et al. Plant Mol Biol, 2011 Jan. PMID 21052784
    4. Systemic and intracellular responses to photooxidative stress in Arabidopsis. Rossel JB, et al. Plant Cell, 2007 Dec. PMID 18156220, Free PMC Article
    5. Identification and characterization of COI1-dependent transcription factor genes involved in JA-mediated response to wounding in Arabidopsis plants. Wang Z, et al. Plant Cell Rep, 2008 Jan. PMID 17786451

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In conditions of red light-induced defence, Arabidopsis LOX activity and transcription levels of LOX2, LOX3, and LOX4 were both upregulated.
      Title: Phytochrome B-mediated activation of lipoxygenase modulates an excess red light-induced defence response in Arabidopsis.
    2. The jasmonic acid (JA) pathway was activated more in kor1-1 plants with an increase in the JA-biosynthesis gene LOX3 and a greater accumulation of JA. Upon infection the accumulation of JA and JA-isoleucine (JA-Ile) was higher than in wild-type plants.
      Title: Absence of endo-1,4-β-glucanase KOR1 alters the jasmonate-dependent defence response to Pseudomonas syringae in Arabidopsis.
    3. Data show that deficiency in LOX3(At1g17420) and LOX4 (At1g72520) causes developmental dysfunctions, compared to wild type, and lox3 lox4 double mutants are taller and develop more inflorescence shoots and flowers.
      Title: Arabidopsis lox3 lox4 double mutants are male sterile and defective in global proliferative arrest.
    4. AtLOX-2, AtLOX-3, AtLOX-4 and AtLOX-6 are 13S-lipoxygenases.
      Title: Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_101603.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables linoleate 13S-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anther dehiscence IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within anther development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oxylipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to high light intensity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within stamen filament development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    lipoxygenase 3
    NP_564021.1
    • lipoxygenase 3 (LOX3); FUNCTIONS IN: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, lipoxygenase activity, iron ion binding, metal ion binding; INVOLVED IN: growth, response to fungus, jasmonic acid biosynthetic process, response to wounding, defense response; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Lipoxygenase, iron binding site (InterPro:IPR020833), Lipoxygenase, C-terminal (InterPro:IPR013819), Lipoxygenase, LH2 (InterPro:IPR001024), Lipase/lipooxygenase, PLAT/LH2 (InterPro:IPR008976), Lipoxygenase, conserved site (InterPro:IPR020834), Lipoxygenase (InterPro:IPR000907), Lipoxygenase, plant (InterPro:IPR001246); BEST Arabidopsis thaliana protein match is: PLAT/LH2 domain-containing lipoxygenase family protein (TAIR:AT1G72520.1); Has 1470 Blast hits to 1436 proteins in 179 species: Archae - 0; Bacteria - 76; Metazoa - 529; Fungi - 49; Plants - 787; Viruses - 0; Other Eukaryotes - 29 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5977323..5981521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101603.3 → NP_564021.1  lipoxygenase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564021.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LNR3, Q9LQJ5, Q9SMW1
      UniProtKB/TrEMBL
      A0A5S9UV07, A0A654EAN8
      Conserved Domains (1) summary
      PLN02264
      Location:1 → 919
      PLN02264; lipoxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LNR3.1

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