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    PIP5K2 phosphatidylinositol-4-phosphate 5-kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844110, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PIP5K2
    Official Full Name
    phosphatidylinositol-4-phosphate 5-kinase 2
    Primary source
    TAIR:AT1G77740
    Locus tag
    AT1G77740
    See related
    Araport:AT1G77740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    phosphatidylinositol-4-phosphate 5-kinase 2
    Summary
    Encodes PIP5K2, a phosphatidylinositol-4-phosphate 5-kinase (PtdIns(4)P 5-kinase 2; or PIP5K2 that is involved in regulating lateral root formation and root gravity response.
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    Genomic context

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    See PIP5K2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (29220349..29224426)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene putative protein kinase 1 Neighboring gene Pleckstrin homology (PH) domain superfamily protein Neighboring gene Ribosomal protein S13/S18 family Neighboring gene nitrate reductase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis phosphatidylinositol 4-phosphate 5-kinase 2 contains a functional nuclear localization sequence and interacts with alpha-importins. Gerth K, et al. Plant J, 2017 Dec. PMID 28949047
    2. Phosphatidylinositol 4-phosphate 5-kinases 1 and 2 are involved in the regulation of vacuole morphology during Arabidopsis thaliana pollen development. Ugalde JM, et al. Plant Sci, 2016 Sep. PMID 27457979
    3. Arabidopsis phosphatidylinositol monophosphate 5-kinase 2 is involved in root gravitropism through regulation of polar auxin transport by affecting the cycling of PIN proteins. Mei Y, et al. Cell Res, 2012 Mar. PMID 21894193, Free PMC Article
    4. Arabidopsis Rab-E GTPases exhibit a novel interaction with a plasma-membrane phosphatidylinositol-4-phosphate 5-kinase. Camacho L, et al. J Cell Sci, 2009 Dec 1. PMID 19903693
    5. The Arabidopsis Phosphatidylinositol Phosphate 5-Kinase PIP5K3 is a key regulator of root hair tip growth. Kusano H, et al. Plant Cell, 2008 Feb. PMID 18281506, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. contains a functional nuclear localization sequence and interacts with alpha-importins
      Title: Arabidopsis phosphatidylinositol 4-phosphate 5-kinase 2 contains a functional nuclear localization sequence and interacts with alpha-importins.
    2. PIP5K1 and PIP5K2 are expressed during early stages of pollen development and their transcriptional activity respond to auxin in pollen grains. PIP5K1, PIP5K2 and phosphoinositide signaling are important cues for early developmental stages and vacuole formation during microgametogenesis.
      Title: Phosphatidylinositol 4-phosphate 5-kinases 1 and 2 are involved in the regulation of vacuole morphology during Arabidopsis thaliana pollen development.
    3. PIP5K2 is involved in regulating lateral root formation and root gravity response, and reveal a critical role of PIP5K2/PtdIns(4,5)P(2) in root development through regulation of PIN proteins, providing direct evidence of crosstalk between the phosphatidylinositol signaling pathway and auxin response, and new insights into the control of polar auxin transport
      Title: Arabidopsis phosphatidylinositol monophosphate 5-kinase 2 is involved in root gravitropism through regulation of polar auxin transport by affecting the cycling of PIN proteins.
    4. Data propose that plant cells exhibit a novel interaction in which PIP5K2 binds GTP-bound Rab-E proteins, which may stimulate temporally or spatially localized PtdIns(4,5)P(2) production at the plasma membrane.
      Title: Arabidopsis Rab-E GTPases exhibit a novel interaction with a plasma-membrane phosphatidylinositol-4-phosphate 5-kinase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001334792.1
    NM_106423.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within developmental process involved in reproduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lateral root formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive gravitropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol-4-phosphate 5-kinase 2
    NP_001319397.1
    • phosphatidylinositol-4-phosphate 5-kinase 2 (PIP5K2); CONTAINS InterPro DOMAIN/s: Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup (InterPro:IPR016034), Phosphatidylinositol-4-phosphate 5-kinase, plant (InterPro:IPR017163), MORN motif (InterPro:IPR003409), Phosphatidylinositol-4-phosphate 5-kinase, core (InterPro:IPR002498); BEST Arabidopsis thaliana protein match is: phosphatidylinositol-4-phosphate 5-kinase 1 (TAIR:AT1G21980.1); Has 28568 Blast hits to 7904 proteins in 613 species: Archae - 0; Bacteria - 4095; Metazoa - 4135; Fungi - 445; Plants - 2701; Viruses - 0; Other Eukaryotes - 17192 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29220349..29224426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334792.1 → NP_001319397.1  phosphatidylinositol-4-phosphate 5-kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L796, Q9CA20
      UniProtKB/TrEMBL
      A0A178W978, A0A5S9WV91
      Conserved Domains (1) summary
      PLN03185
      Location:73 → 750
      PLN03185; phosphatidylinositol phosphate kinase; Provisional

    2. NM_106423.2 → NP_177897.1  phosphatidylinositol-4-phosphate 5-kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177897.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L796, Q9CA20
      UniProtKB/TrEMBL
      A0A178W978, A0A5S9WV91
      Conserved Domains (1) summary
      PLN03185
      Location:73 → 750
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L796.2

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