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    NFU4 NFU domain protein 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821647, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NFU4
    Official Full Name
    NFU domain protein 4
    Primary source
    TAIR:AT3G20970
    Locus tag
    AT3G20970
    See related
    Araport:AT3G20970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA NFU DOMAIN PROTEIN 2; ATNFU2; NFU domain protein 4
    Summary
    Encodes a protein containing the NFU domain that may be involved in iron-sulfur cluster assembly. Part of a five member gene family, more closely related to NFU5 than to NFU1,2, and 3. Targeted to the mitochondrion.
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    Genomic context

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    See NFU4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (7348157..7350341)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 32 Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 33 Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Gag-Pol-related retrotransposon family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis chloroplastic NifU-like protein CnfU, which can act as an iron-sulfur cluster scaffold protein, is required for biogenesis of ferredoxin and photosystem I. Yabe T, et al. Plant Cell, 2004 Apr. PMID 15031412, Free PMC Article
    2. Iron-sulphur cluster assembly in plants: distinct NFU proteins in mitochondria and plastids from Arabidopsis thaliana. Léon S, et al. Biochem J, 2003 May 1. PMID 12553879, Free PMC Article
    3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035658.1
    NM_112989.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within iron-sulfur cluster assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NFU domain protein 4
    NP_001030735.1
    • NFU domain protein 4 (NFU4); CONTAINS InterPro DOMAIN/s: NIF system FeS cluster assembly, NifU, C-terminal (InterPro:IPR001075), HIRA-interacting protein 5 (InterPro:IPR017065), NIF system FeS cluster assembly, NifU-like scaffold, N-terminal (InterPro:IPR014824); BEST Arabidopsis thaliana protein match is: NFU domain protein 5 (TAIR:AT1G51390.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_566673.1
    • NFU domain protein 4 (NFU4); CONTAINS InterPro DOMAIN/s: NIF system FeS cluster assembly, NifU, C-terminal (InterPro:IPR001075), HIRA-interacting protein 5 (InterPro:IPR017065), NIF system FeS cluster assembly, NifU-like scaffold, N-terminal (InterPro:IPR014824); BEST Arabidopsis thaliana protein match is: NFU domain protein 5 (TAIR:AT1G51390.1); Has 6036 Blast hits to 5990 proteins in 1590 species: Archae - 18; Bacteria - 3114; Metazoa - 168; Fungi - 162; Plants - 179; Viruses - 3; Other Eukaryotes - 2392 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7348157..7350341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112989.3 → NP_566673.1  NFU domain protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566673.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LIG6
      UniProtKB/TrEMBL
      A0A7G2EMB1
      Conserved Domains (2) summary
      smart00932
      Location:82 → 168
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      COG0694
      Location:187 → 273
      NifU; Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, protein turnover, chaperones]

    2. NM_001035658.1 → NP_001030735.1  NFU domain protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030735.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EK36, F4IWC5
      Conserved Domains (2) summary
      smart00932
      Location:82 → 168
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      cl00484
      Location:187 → 222
      NifU; NifU-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LIG6.1

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