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    SAP5 A20/AN1-like zinc finger family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820443, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAP5
    Official Full Name
    A20/AN1-like zinc finger family protein
    Primary source
    TAIR:AT3G12630
    Locus tag
    AT3G12630
    See related
    Araport:AT3G12630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    stress associated protein 5
    Summary
    Encodes a protein with E3 ligase activity that acts as a positive regulator of stress responses in Arabidopsis.
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    Genomic context

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    See SAP5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (4012107..4013583)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene Protein phosphatase 2C family protein Neighboring gene RNA binding (RRM/RBD/RNP motifs) family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis SAP5 functions as a positive regulator of stress responses and exhibits E3 ubiquitin ligase activity. Kang M, et al. Plant Mol Biol, 2011 Mar. PMID 21293909
    2. Identification of HSP90C as a substrate of E3 ligase TaSAP5 through ubiquitylome profiling. Zhang N, et al. Plant Sci, 2019 Oct. PMID 31481192
    3. Polyubiquitin recognition by AtSAP5, an A20-type zinc finger containing protein from Arabidopsis thaliana. Choi H, et al. Biochem Biophys Res Commun, 2012 Mar 9. PMID 22366090
    4. AtMBP-1, an alternative translation product of LOS2, affects abscisic acid responses and is modulated by the E3 ubiquitin ligase AtSAP5. Kang M, et al. Plant J, 2013 Nov. PMID 23952686
    5. VH1/BRL2 receptor-like kinase interacts with vascular-specific adaptor proteins VIT and VIK to influence leaf venation. Ceserani T, et al. Plant J, 2009 Mar. PMID 19000166, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. While constitutive expression of MBP-1 leads to increased sensitivity to abscisic acid and stunted vegetative growth, the growth defect can be reversed by co-expression of SAP5.
      Title: AtMBP-1, an alternative translation product of LOS2, affects abscisic acid responses and is modulated by the E3 ubiquitin ligase AtSAP5.
    2. AtSAP5 participates in polyubiquitin recognition in plants and that the dialipathic patch in AtSAP5 is critical in binding K48-linked polyubiquitn chains.
      Title: Polyubiquitin recognition by AtSAP5, an A20-type zinc finger containing protein from Arabidopsis thaliana.
    3. SAP5, one member of the Stress Associated Protein gene family, was identified by its expression in response to salinity, osmotic, drought and cold stress. SAP5 has E3 ligase activity and acts as a positive regulator of stress responses. [SAP5]
      Title: Arabidopsis SAP5 functions as a positive regulator of stress responses and exhibits E3 ubiquitin ligase activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112098.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    A20/AN1-like zinc finger family protein
    NP_566429.1
    • A20/AN1-like zinc finger family protein; FUNCTIONS IN: DNA binding, zinc ion binding; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, AN1-type (InterPro:IPR000058), Zinc finger, A20-type (InterPro:IPR002653); BEST Arabidopsis thaliana protein match is: A20/AN1-like zinc finger family protein (TAIR:AT2G36320.1); Has 1013 Blast hits to 1009 proteins in 143 species: Archae - 0; Bacteria - 0; Metazoa - 428; Fungi - 9; Plants - 446; Viruses - 6; Other Eukaryotes - 124 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4012107..4013583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112098.2 → NP_566429.1  A20/AN1-like zinc finger family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566429.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LHJ8
      UniProtKB/TrEMBL
      A0A178VGK6, A0A5S9XBF1
      Conserved Domains (1) summary
      smart00154
      Location:101 → 138
      ZnF_AN1; AN1-like Zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LHJ8.1

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