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    CBL5 calcineurin B-like protein 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826671, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CBL5
    Official Full Name
    calcineurin B-like protein 5
    Primary source
    TAIR:AT4G01420
    Locus tag
    AT4G01420
    See related
    Araport:AT4G01420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    calcineurin B-like protein 5; F3D13.2; F3D13_2
    Summary
    Encodes calcineurin B-like protein 5 (CBL5). Overexpression confers tolerance to drought and salt stress.
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    Genomic context

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    See CBL5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (580038..581521, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene conserved oligomeric Golgi complex subunit 4 Neighboring gene oligomeric golgi complex subunit-like protein Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene miscRNA Neighboring gene nodulin MtN21 /EamA-like transporter family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Constitutive overexpression of the calcium sensor CBL5 confers osmotic or drought stress tolerance in Arabidopsis. Cheong YH, et al. Mol Cells, 2010 Feb 28. PMID 20077023
    2. N-myristoylation and S-acylation are common modifications of Ca(2+) -regulated Arabidopsis kinases and are required for activation of the SLAC1 anion channel. Saito S, et al. New Phytol, 2018 Jun. PMID 29498046
    3. Calcineurin B-like protein CBL10 directly interacts with AKT1 and modulates K+ homeostasis in Arabidopsis. Ren XL, et al. Plant J, 2013 Apr. PMID 23331977
    4. CBL-mediated targeting of CIPKs facilitates the decoding of calcium signals emanating from distinct cellular stores. Batistic O, et al. Plant J, 2010 Jan. PMID 19832944
    5. A protein kinase, calcineurin B-like protein-interacting protein Kinase9, interacts with calcium sensor calcineurin B-like Protein3 and regulates potassium homeostasis under low-potassium stress in Arabidopsis. Liu LL, et al. Plant Physiol, 2013 Jan. PMID 23109687, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLAC1 activation by CPK6 or CBL5-CIPK11 was strictly dependent on dual lipid modification.
      Title: N-myristoylation and S-acylation are common modifications of Ca(2+) -regulated Arabidopsis kinases and are required for activation of the SLAC1 anion channel.
    2. These results suggest that CBL5 may function as a positive regulator of salt or drought responses in plants.
      Title: Constitutive overexpression of the calcium sensor CBL5 confers osmotic or drought stress tolerance in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001340311.1
    NM_116372.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium-mediated signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    calcineurin B-like protein 5
    NP_192051.2
    • calcineurin B-like protein 5 (CBL5); FUNCTIONS IN: calcium ion binding; INVOLVED IN: response to salt stress, response to water deprivation, N-terminal protein myristoylation, calcium-mediated signaling, response to osmotic stress; LOCATED IN: cellular_component unknown; EXPRESSED IN: stem, flower, leaf; CONTAINS InterPro DOMAIN/s: Recoverin (InterPro:IPR001125), EF-HAND 2 (InterPro:IPR018249), Calcineurin B protein (InterPro:IPR015757), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: Calcium-binding EF-hand family protein (TAIR:AT5G24270.2); Has 5545 Blast hits to 5527 proteins in 657 species: Archae - 0; Bacteria - 7; Metazoa - 2787; Fungi - 925; Plants - 1302; Viruses - 0; Other Eukaryotes - 524 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      580038..581521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116372.3 → NP_192051.2  calcineurin B-like protein 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192051.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81328, Q7FZF1
      Conserved Domains (1) summary
      COG5126
      Location:13 → 181
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_001340311.1 → NP_001329076.1  calcineurin B-like protein 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UXP4, A0A1P8B6M3, A0A384KKX9
      Conserved Domains (1) summary
      COG5126
      Location:13 → 181
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7FZF1.3

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