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    ATSTE24 Peptidase family M48 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828209, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATSTE24
    Official Full Name
    Peptidase family M48 family protein
    Primary source
    TAIR:AT4G01320
    Locus tag
    AT4G01320
    See related
    Araport:AT4G01320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2N1.21; F2N1_21; STE24
    Summary
    CAAX protease with broad substrate specificity. Localized exclusively to the endoplasmic reticulum.
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    Genomic context

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    See ATSTE24 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    15
    Sequence:
    Chromosome: 4; NC_003075.7 (545796..549413)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Homeodomain-like superfamily protein Neighboring gene chorismate synthase Neighboring gene Ribosomal L5P family protein Neighboring gene Protein kinase superfamily protein Neighboring gene TATA box-binding protein associated factor RNA polymerase I subunit B-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis AtSTE24 is a CAAX protease with broad substrate specificity. Bracha K, et al. J Biol Chem, 2002 Aug 16. PMID 12039957
    2. Focal segmental glomerulosclerosis in patients with mandibuloacral dysplasia owing to ZMPSTE24 deficiency. Agarwal AK, et al. J Investig Med, 2006 May. PMID 17152860
    3. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502
    4. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
    5. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001340307.1
    NM_001340308.1
    NM_116362.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within CAAX-box protein maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in CAAX-box protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Peptidase family M48 family protein
    NP_567212.1
    • ATSTE24; FUNCTIONS IN: endopeptidase activity, metalloendopeptidase activity; INVOLVED IN: CAAX-box protein maturation, proteolysis; LOCATED IN: endoplasmic reticulum, vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M48 (InterPro:IPR001915); Has 2991 Blast hits to 2984 proteins in 996 species: Archae - 162; Bacteria - 1572; Metazoa - 206; Fungi - 172; Plants - 49; Viruses - 0; Other Eukaryotes - 830 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      545796..549413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116362.3 → NP_567212.1  Peptidase family M48 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567212.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04602, Q8RX88, Q93ZV9, Q94FS8, Q9M139
      UniProtKB/TrEMBL
      A0A5S9XP58, A0A654FKU9
      Conserved Domains (1) summary
      cd07343
      Location:8 → 417
      M48A_Zmpste24p_like; Peptidase M48 subfamily A, a type 1 CaaX endopeptidase

    2. NM_001340307.1 → NP_001329598.1  Peptidase family M48 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UVF3, A0A1P8B870, A0A384LG78

    3. NM_001340308.1 → NP_001329597.1  Peptidase family M48 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UVF3, A0A1P8B870, A0A384LG78
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RX88.1

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