NSF AAA-type ATPase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: NSF
Official Full Name: AAA-type ATPase family protein
Primary source: TAIR:AT4G04910
Locus tag: AT4G04910
See related: Araport:AT4G04910
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: N-ethylmaleimide sensitive factor; T1J1.4; T1J1_4
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See NSF in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 21

Sequence:: Chromosome: 4; NC_003075.7 (2489364..2495863, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mutant phenotype to the missense mutation D374N in the NSF gene, encoding the N-ethylmaleimide-sensitive factor, was linked a key component of membrane fusion.
Title: A Missense Mutation in the NSF Gene Causes Abnormal Golgi Morphology in Arabidopsis thaliana.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_116729.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SNARE complex disassembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle-mediated transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: AAA-type ATPase family protein

NP_192400.2

N-ethylmaleimide sensitive factor (NSF); FUNCTIONS IN: protein binding; LOCATED IN: vacuole; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA-type, conserved site (InterPro:IPR003960), Aspartate decarboxylase-like fold (InterPro:IPR009010), Cell division protein 48, CDC48, domain 2 (InterPro:IPR004201), ATPase, AAA-type, VAT, N-terminal (InterPro:IPR003338); BEST Arabidopsis thaliana protein match is: cell division cycle 48 (TAIR:AT3G09840.1); Has 30539 Blast hits to 27448 proteins in 3106 species: Archae - 1540; Bacteria - 10808; Metazoa - 4854; Fungi - 3637; Plants - 2891; Viruses - 27; Other Eukaryotes - 6782 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

2489364..2495863 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116729.4 → NP_192400.2 AAA-type ATPase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192400.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9M0Y8, Q9ZPH6

UniProtKB/TrEMBL

A0A178UTB9, A0A5S9XQM4, A0A654FM63

Conserved Domains (4) summary

smart01073
Location:12 → 92

CDC48_N; Cell division protein 48 (CDC48) N-terminal domain

COG0464
Location:239 → 648

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

pfam02933
Location:118 → 173

CDC48_2; Cell division protein 48 (CDC48), domain 2

cd19504
Location:216 → 392

RecA-like_NSF-SEC18_r1-like; first of two ATPase domains of NSF and SEC18, and similar ATPase domains