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    CRK5 cysteine-rich RLK (RECEPTOR-like protein kinase) 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828412, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CRK5
    Official Full Name
    cysteine-rich RLK (RECEPTOR-like protein kinase) 5
    Primary source
    TAIR:AT4G23130
    Locus tag
    AT4G23130
    See related
    Araport:AT4G23130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cysteine-rich RLK (RECEPTOR-like protein kinase) 5; F7H19.320; F7H19_320; RECEPTOR-LIKE PROTEIN KINASE 6; RLK6
    Summary
    Encodes a receptor-like protein kinase. Naming convention from Chen et al 2003 (PMID 14756307)
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    Genomic context

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    See CRK5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (12117491..12120220, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein Neighboring gene Bromo-adjacent homology (BAH) domain-containing protein Neighboring gene cysteine-rich RLK (RECEPTOR-like protein kinase) 6 Neighboring gene cysteine-rich RLK (RECEPTOR-like protein kinase) 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of an Arabidopsis cysteine-rich receptor-like protein kinase, CRK5, enhances abscisic acid sensitivity and confers drought tolerance. Lu K, et al. J Exp Bot, 2016 Sep. PMID 27406784, Free PMC Article
    2. Cysteine-rich receptor-like kinase CRK5 as a regulator of growth, development, and ultraviolet radiation responses in Arabidopsis thaliana. Burdiak P, et al. J Exp Bot, 2015 Jun. PMID 25969551, Free PMC Article
    3. The AtCRK5 Protein Kinase Is Required to Maintain the ROS NO Balance Affecting the PIN2-Mediated Root Gravitropic Response in Arabidopsis. Cséplő Á, et al. Int J Mol Sci, 2021 Jun 1. PMID 34205973, Free PMC Article
    4. Inactivation of plasma membrane-localized CDPK-RELATED KINASE5 decelerates PIN2 exocytosis and root gravitropic response in Arabidopsis. Rigó G, et al. Plant Cell, 2013 May. PMID 23673979, Free PMC Article
    5. Activation of hypersensitive cell death by pathogen-induced receptor-like protein kinases from Arabidopsis. Chen K, et al. Plant Mol Biol, 2004 Sep. PMID 15604743

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The AtCRK5 Protein Kinase Is Required to Maintain the ROS NO Balance Affecting the PIN2-Mediated Root Gravitropic Response in Arabidopsis.
      Title: The AtCRK5 Protein Kinase Is Required to Maintain the ROS NO Balance Affecting the PIN2-Mediated Root Gravitropic Response in Arabidopsis.
    2. overexpression enhances abscisic acid sensitivity and confers drought tolerance
      Title: Overexpression of an Arabidopsis cysteine-rich receptor-like protein kinase, CRK5, enhances abscisic acid sensitivity and confers drought tolerance.
    3. CRK5 plays an essential role in the regulation of growth, development, and acclimatory responses in Arabidopsis thaliana.
      Title: Cysteine-rich receptor-like kinase CRK5 as a regulator of growth, development, and ultraviolet radiation responses in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001341575.1
    NM_118442.4
    NM_179094.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cysteine-rich RLK (RECEPTOR-like protein kinase) 5
    NP_567677.1
    • cysteine-rich RLK (RECEPTOR-like protein kinase) 5 (CRK5); FUNCTIONS IN: kinase activity; INVOLVED IN: defense response to bacterium, programmed cell death, response to salicylic acid stimulus; LOCATED IN: endomembrane system; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Protein of unknown function DUF26 (InterPro:IPR002902), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: cysteine-rich RLK (RECEPTOR-like protein kinase) 4 (TAIR:AT3G45860.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_849425.1
    • cysteine-rich RLK (RECEPTOR-like protein kinase) 5 (CRK5); FUNCTIONS IN: kinase activity; INVOLVED IN: defense response to bacterium, programmed cell death, response to salicylic acid stimulus; LOCATED IN: endomembrane system; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Protein of unknown function DUF26 (InterPro:IPR002902), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cysteine-rich RLK (RECEPTOR-like protein kinase) 4 (TAIR:AT3G45860.1); Has 121629 Blast hits to 120099 proteins in 4447 species: Archae - 100; Bacteria - 13629; Metazoa - 44864; Fungi - 10560; Plants - 34243; Viruses - 400; Other Eukaryotes - 17833 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12117491..12120220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118442.4 → NP_567677.1  cysteine-rich RLK (RECEPTOR-like protein kinase) 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567677.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65465, Q8H1S3, Q9C5S8
      UniProtKB/TrEMBL
      A0A654FRY3
      Conserved Domains (3) summary
      smart00221
      Location:345 → 612
      STYKc; Protein kinase; unclassified specificity
      cd14066
      Location:346 → 613
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam01657
      Location:35 → 128
      Stress-antifung; Salt stress response/antifungal

    2. NM_179094.3 → NP_849425.1  cysteine-rich RLK (RECEPTOR-like protein kinase) 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849425.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XVH5, A0A654FRY3
      Conserved Domains (2) summary
      cd14066
      Location:350 → 617
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam01657
      Location:37 → 128
      Stress-antifung; Salt stress response/antifungal

    3. NM_001341575.1 → NP_001329890.1  cysteine-rich RLK (RECEPTOR-like protein kinase) 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B944, A0A654FRY3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5S8.1

    Gene LinkOut

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