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    FLDH NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829473, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FLDH
    Official Full Name
    NAD(P)-binding Rossmann-fold superfamily protein
    Primary source
    TAIR:AT4G33360
    Locus tag
    AT4G33360
    See related
    Araport:AT4G33360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F17M5.120; F17M5_120; farnesol dehydrogenase
    Summary
    Encodes an NAD+-dependent dehydrogenase that oxidizes farnesol more efficiently than other prenyl alcohol substrates.
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    Genomic context

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    See FLDH in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (16067672..16069374, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene plant glycogenin-like starch initiation protein 3 Neighboring gene Tic22-like family protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene DEA(D/H)-box RNA helicase family protein Neighboring gene dimethylallyl, adenosine tRNA methylthiotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis. Bhandari J, et al. Plant Physiol, 2010 Nov. PMID 20807998, Free PMC Article
    2. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
    3. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
    4. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
    5. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. At4g33360 (FLDH) encodes an enzyme with farnesol dehydrogenase activity, and is regulated by abscisic acid.
      Title: Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001125637.1
    NM_001203973.1
    NM_119490.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables farnesol dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within farnesol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    NAD(P)-binding Rossmann-fold superfamily protein
    NP_001119109.1
    • farnesol dehydrogenase (FLDH); FUNCTIONS IN: farnesol dehydrogenase activity; INVOLVED IN: terpenoid metabolic process, farnesol metabolic process; LOCATED IN: endoplasmic reticulum, plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT1G09490.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_001190902.1
    • farnesol dehydrogenase (FLDH); CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT1G09490.1).
    NP_195062.1
    • farnesol dehydrogenase (FLDH); FUNCTIONS IN: farnesol dehydrogenase activity; INVOLVED IN: terpenoid metabolic process, farnesol metabolic process; LOCATED IN: endoplasmic reticulum, plasma membrane, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT1G09490.1); Has 32553 Blast hits to 32549 proteins in 3005 species: Archae - 643; Bacteria - 21240; Metazoa - 691; Fungi - 1000; Plants - 2475; Viruses - 74; Other Eukaryotes - 6430 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16067672..16069374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119490.2 → NP_195062.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195062.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FV62, Q94CD9, Q9SZB3
      Conserved Domains (1) summary
      cd05228
      Location:15 → 336
      AR_FR_like_1_SDR_e; uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs

    2. NM_001125637.1 → NP_001119109.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119109.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3H6K6, Q94CD9
      Conserved Domains (2) summary
      cd05228
      Location:15 → 300
      AR_FR_like_1_SDR_e; uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs
      pfam01370
      Location:15 → 241
      Epimerase; NAD dependent epimerase/dehydratase family

    3. NM_001203973.1 → NP_001190902.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190902.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JIW8, Q94CD9
      Conserved Domains (2) summary
      TIGR03466
      Location:1 → 319
      HpnA; hopanoid-associated sugar epimerase
      cd05228
      Location:3 → 322
      AR_FR_like_1_SDR_e; uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs
    Nucleotide Protein
    Heading Accession and Version

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