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    VHA-A3 vacuolar proton ATPase A3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830063, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VHA-A3
    Official Full Name
    vacuolar proton ATPase A3
    Primary source
    TAIR:AT4G39080
    Locus tag
    AT4G39080
    See related
    Araport:AT4G39080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F19H22.180; F19H22_180; vacuolar proton ATPase A3
    Summary
    Vacuolar proton ATPase subunit VHA-a isoform 3. Localized in the tonoplast.
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    Genomic context

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    See VHA-A3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Sequence:
    Chromosome: 4; NC_003075.7 (18209399..18215204)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene LOW protein: coatomer subunit alpha-1-like protein Neighboring gene B-box zinc finger family protein Neighboring gene Papain family cysteine protease Neighboring gene PHD finger family protein / bromo-adjacent homology (BAH) domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tonoplast proton pumps regulate nuclear spacing of female gametophytes via mediating polar auxin transport in Arabidopsis. Jiang YT, et al. Front Plant Sci, 2022. PMID 36176689, Free PMC Article
    2. A Defective Vacuolar Proton Pump Enhances Aluminum Tolerance by Reducing Vacuole Sequestration of Organic Acids. Zhang F, et al. Plant Physiol, 2019 Oct. PMID 31350362, Free PMC Article
    3. Tonoplast targeting of VHA-a3 relies on a Rab5-mediated but Rab7-independent vacuolar trafficking route. Feng QN, et al. J Integr Plant Biol, 2017 Apr. PMID 28198146
    4. Vacuolar H+-ATPase activity is required for endocytic and secretory trafficking in Arabidopsis. Dettmer J, et al. Plant Cell, 2006 Mar. PMID 16461582, Free PMC Article
    5. Vacuolar H(+)-ATPase and BZR1 form a feedback loop to regulate the homeostasis of BR signaling in Arabidopsis. Jiang YT, et al. Mol Plant, 2023 Dec 4. PMID 37837193

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vacuolar H[+]-ATPase and BZR1 form a feedback loop to regulate the homeostasis of BR signaling in Arabidopsis.
      Title: Vacuolar H(+)-ATPase and BZR1 form a feedback loop to regulate the homeostasis of BR signaling in Arabidopsis.
    2. A Defective Vacuolar Proton Pump Enhances Aluminum Tolerance by Reducing Vacuole Sequestration of Organic Acids.
      Title: A Defective Vacuolar Proton Pump Enhances Aluminum Tolerance by Reducing Vacuole Sequestration of Organic Acids.
    3. VHA-a3 targets to the tonoplast through a Rab5-mediated but Rab7-independent pathway, shedding new lights on the unconventional vacuolar trafficking route in plant cells.[VHA-a3]
      Title: Tonoplast targeting of VHA-a3 relies on a Rab5-mediated but Rab7-independent vacuolar trafficking route.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_120068.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables diphosphate hydrolysis-driven proton transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to nutrient levels IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT involved_in cellular response to salt stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within proton motive force-driven ATP synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of auxin polar transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sequestering of zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar sequestering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in vacuolar membrane HDA PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    vacuolar proton ATPase A3
    NP_568051.1
    • vacuolar proton ATPase A3 (VHA-A3); FUNCTIONS IN: ATPase activity, hydrogen-translocating pyrophosphatase activity; INVOLVED IN: cellular response to nutrient levels, ATP synthesis coupled proton transport; LOCATED IN: in 7 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, V0/A0 complex, 116kDa subunit (InterPro:IPR002490); BEST Arabidopsis thaliana protein match is: vacuolar proton ATPase A2 (TAIR:AT2G21410.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      18209399..18215204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120068.5 → NP_568051.1  vacuolar proton ATPase A3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568051.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WLI9, Q42216, Q56WQ9, Q8W4S4, Q9SVI5
      UniProtKB/TrEMBL
      A0A178V3A8, A0A5S9XZZ4, A0A654FXD2
      Conserved Domains (1) summary
      pfam01496
      Location:39 → 813
      V_ATPase_I; V-type ATPase 116kDa subunit family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W4S4.1

    Gene LinkOut

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