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    TGH SWAP (Suppressor-of-White-APricot)/surp domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832372, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TGH
    Official Full Name
    SWAP (Suppressor-of-White-APricot)/surp domain-containing protein
    Primary source
    TAIR:AT5G23080
    Locus tag
    AT5G23080
    See related
    Araport:AT5G23080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MYJ24.7; MYJ24_7; TOUGH
    Summary
    Interacts with TATA-box binding protein 2. Contains domains with strong similarity to G-patch and SWAP domains, characteristic of RNA binding and processing proteins. Colocalizes with the splicing regulator SRp34 to subnuclear particles. It is an important component of miRNA and siRNA biogenesis. Mutants display developmental defects, including reduced plant height, polycotyly, and reduced vascularization. Strong genetic interaction between TGH and AMP1.
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    Genomic context

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    See TGH in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (7742940..7749020, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene Thymidine kinase Neighboring gene nuclear factor Y, subunit B13 Neighboring gene MIZU-KUSSEI-like protein (Protein of unknown function, DUF617)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of miRNA abundance by RNA binding protein TOUGH in Arabidopsis. Ren G, et al. Proc Natl Acad Sci U S A, 2012 Jul 31. PMID 22802657, Free PMC Article
    2. The evolutionarily conserved TOUGH protein is required for proper development of Arabidopsis thaliana. Calderon-Villalobos LI, et al. Plant Cell, 2005 Sep. PMID 16024589, Free PMC Article
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001036849.2
    NM_122214.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables pre-miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables primary miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in auxin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SWAP (Suppressor-of-White-APricot)/surp domain-containing protein
    NP_001031926.1
    • TOUGH (TGH); FUNCTIONS IN: protein binding, RNA binding; INVOLVED IN: multicellular organismal development, phloem or xylem histogenesis, RNA processing; LOCATED IN: nucleus; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF1604 (InterPro:IPR011666), SWAP/Surp (InterPro:IPR000061); Has 34900 Blast hits to 18983 proteins in 949 species: Archae - 12; Bacteria - 1329; Metazoa - 18979; Fungi - 3127; Plants - 2236; Viruses - 165; Other Eukaryotes - 9052 (source: NCBI BLink).
    NP_197699.2
    • TOUGH (TGH); FUNCTIONS IN: protein binding, RNA binding; INVOLVED IN: multicellular organismal development, phloem or xylem histogenesis, RNA processing; LOCATED IN: nucleus; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF1604 (InterPro:IPR011666), SWAP/Surp (InterPro:IPR000061); Has 34939 Blast hits to 19000 proteins in 961 species: Archae - 12; Bacteria - 1387; Metazoa - 18982; Fungi - 3122; Plants - 2233; Viruses - 162; Other Eukaryotes - 9041 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7742940..7749020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122214.4 → NP_197699.2  SWAP (Suppressor-of-White-APricot)/surp domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197699.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GXN9, Q9FN46
      UniProtKB/TrEMBL
      A0A654G3D7
      Conserved Domains (2) summary
      pfam01805
      Location:405 → 452
      Surp; Surp module
      pfam07713
      Location:39 → 120
      DUF1604; Protein of unknown function (DUF1604)

    2. NM_001036849.2 → NP_001031926.1  SWAP (Suppressor-of-White-APricot)/surp domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031926.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654G3D7
      Conserved Domains (2) summary
      pfam01805
      Location:375 → 422
      Surp; Surp module
      pfam07713
      Location:39 → 120
      DUF1604; Protein of unknown function (DUF1604)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GXN9.1

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