MAM1 methylthioalkylmalate synthase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: MAM1
Official Full Name: methylthioalkylmalate synthase 1
Primary source: TAIR:AT5G23010
Locus tag: AT5G23010
See related: Araport:AT5G23010
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 2-ISOPROPYLMALATE SYNTHASE; 2-ISOPROPYLMALATE SYNTHASE 3; IMS3; METHYLTHIOALKYLMALATE SYNTHASE; methylthioalkylmalate synthase 1; T20O7.3; T20O7_3
Summary: Encodes a methylthioalkylmalate synthase, catalyzes the condensation reactions of the first two rounds of methionine chain elongation in the biosynthesis of methionine-derived glucosinolates.
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

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Changing substrate specificity and iteration of amino acid chain elongation in glucosinolate biosynthesis through targeted mutagenesis of Arabidopsis methylthioalkylmalate synthase 1.
Title: Changing substrate specificity and iteration of amino acid chain elongation in glucosinolate biosynthesis through targeted mutagenesis of Arabidopsis methylthioalkylmalate synthase 1.
We studied the expression patterns of MAM1 and MAM3 genes in different organs and developmental stages using promoter-GUS fusion lines and qRT-PCR.
Title: Expression pattern of the glucosinolate side chain biosynthetic genes MAM1 and MAM3 of Arabidopsis thaliana in different organs and developmental stages.
The C-terminal regulatory domain of IPMS is responsible for Leu feedback inhibition. Loss of the C-terminal domain of IPMS increases MAM activity.
Title: From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis.

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NM_122207.3

Function	Evidence Code	Pubs
NOT enables 2-isopropylmalate synthase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables methylthioalkylmalate synthase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucosinolate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucosinolate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glucosinolate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to insect	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NP_197692.1

methylthioalkylmalate synthase 1 (MAM1); FUNCTIONS IN: 2-(2'-methylthio)ethylmalate synthase activity; INVOLVED IN: glucosinolate biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Alpha-isopropylmalate/homocitrate synthase, conserved site (InterPro:IPR002034), Pyruvate carboxyltransferase (InterPro:IPR000891); BEST Arabidopsis thaliana protein match is: 2-isopropylmalate synthase 2 (TAIR:AT5G23020.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

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