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    SLAH3 SLAC1 homologue 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832468, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SLAH3
    Official Full Name
    SLAC1 homologue 3
    Primary source
    TAIR:AT5G24030
    Locus tag
    AT5G24030
    See related
    Araport:AT5G24030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MZF18.9; MZF18_9; SLAC1 homologue 3
    Summary
    Encodes a protein with ten predicted transmembrane helices. The SLAH3 protein has similarity to the SLAC1 protein involved in ion homeostasis in guard cells. Although it is not expressed in guard cells, it can complement an slac1-2 mutant suggesting that it performs a similar function. SLAH3:GFP localizes to the plasma membrane.
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    Genomic context

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    See SLAH3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (8118317..8122914, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene septum site-determining protein (MIND) Neighboring gene F-box SKIP23-like protein (DUF295) Neighboring gene plant-specific B3-DNA-binding domain protein (DUF313)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis. Lehmann J, et al. Curr Biol, 2021 Aug 23. PMID 34233161
    2. Anion channel SLAH3 functions in nitrate-dependent alleviation of ammonium toxicity in Arabidopsis. Zheng X, et al. Plant Cell Environ, 2015 Mar. PMID 24944085
    3. Kinase SnRK1.1 regulates nitrate channel SLAH3 engaged in nitrate-dependent alleviation of ammonium toxicity. Sun D, et al. Plant Physiol, 2021 May 27. PMID 33560419, Free PMC Article
    4. Anion channel SLAH3 is a regulatory target of chitin receptor-associated kinase PBL27 in microbial stomatal closure. Liu Y, et al. Elife, 2019 Sep 16. PMID 31524595, Free PMC Article
    5. Silent S-Type Anion Channel Subunit SLAH1 Gates SLAH3 Open for Chloride Root-to-Shoot Translocation. Cubero-Font P, et al. Curr Biol, 2016 Aug 22. PMID 27397895

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis.
      Title: Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis.
    2. Kinase SnRK1.1 regulates nitrate channel SLAH3 engaged in nitrate-dependent alleviation of ammonium toxicity.
      Title: Kinase SnRK1.1 regulates nitrate channel SLAH3 engaged in nitrate-dependent alleviation of ammonium toxicity.
    3. Here, the authors show that stomatal closure to fungal chitin is conferred by the major PRRs for chitin recognition, LYK5 and CERK1, the receptor-like cytoplasmic kinase PBL27, and the SLAH3 anion channel. PBL27 has the capacity to phosphorylate SLAH3, of which S127 and S189 are required to activate SLAH3.
      Title: Anion channel SLAH3 is a regulatory target of chitin receptor-associated kinase PBL27 in microbial stomatal closure.
    4. The AtSLAH1 gene is expressed in the root xylem-pole pericycle, where it co-localizes with AtSLAH3. Under high soil salinity, AtSLAH1 expression markedly declined and the chloride content of the xylem sap in AtSLAH1 loss-of-function mutants was half of the wild-type level only. S
      Title: Silent S-Type Anion Channel Subunit SLAH1 Gates SLAH3 Open for Chloride Root-to-Shoot Translocation.
    5. SLAH3, a nitrate efflux channel, plays a role in nitrate-dependent alleviation of ammonium toxicity in plants.
      Title: Anion channel SLAH3 functions in nitrate-dependent alleviation of ammonium toxicity in Arabidopsis.
    6. Pollen tube growth regulation by free anions depends on the interaction between the anion channel SLAH3 and calcium-dependent protein kinases CPK2 and CPK20.
      Title: Pollen tube growth regulation by free anions depends on the interaction between the anion channel SLAH3 and calcium-dependent protein kinases CPK2 and CPK20.
    7. the anion channel SLAH3 is regulated by the ABA signaling pathway
      Title: Arabidopsis nanodomain-delimited ABA signaling pathway regulates the anion channel SLAH3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001343836.1
    NM_122308.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated monoatomic anion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated monoatomic anion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloride transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular monoatomic ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular monoatomic ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SLAC1 homologue 3
    NP_197791.1
    • SLAC1 homologue 3 (SLAH3); FUNCTIONS IN: transporter activity; INVOLVED IN: cellular ion homeostasis; LOCATED IN: integral to membrane, plasma membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: C4-dicarboxylate transporter/malic acid transport protein (InterPro:IPR004695); BEST Arabidopsis thaliana protein match is: SLAC1 homologue 2 (TAIR:AT4G27970.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      8118317..8122914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122308.5 → NP_197791.1  SLAC1 homologue 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197791.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FLV9
      UniProtKB/TrEMBL
      A0A178USC2, A0A5S9Y795
      Conserved Domains (1) summary
      cd09323
      Location:257 → 560
      TDT_SLAC1_like; Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1)

    2. NM_001343836.1 → NP_001332637.1  SLAC1 homologue 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1R7T388
      Conserved Domains (1) summary
      cd09323
      Location:257 → 507
      TDT_SLAC1_like; Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FLV9.1

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