Bms1 BMS1, ribosome biogenesis factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bms1provided by MGI
Official Full Name: BMS1, ribosome biogenesis factorprovided by MGI
Primary source: MGI:MGI:2446132
See related: Ensembl:ENSMUSG00000030138 AllianceGenome:MGI:2446132
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bms1l; mKIAA0187
Summary: Predicted to enable GTP binding activity; GTPase activity; and U3 snoRNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in chromosome; nucleolus; and nucleoplasm. Predicted to be part of small-subunit processome. Human ortholog(s) of this gene implicated in nonsyndromic aplasia cutis congenita. Orthologous to human BMS1 (BMS1 ribosome biogenesis factor). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in CNS E11.5 (RPKM 14.2), liver E14 (RPKM 7.5) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 55.86 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (118360342..118396772, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (118383381..118419802, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124737 (e-PCR)
- UniSTS:161559

RH136358 (e-PCR)
- UniSTS:210348

AU043373 (e-PCR)
- UniSTS:179447

RH125810 (e-PCR)
- UniSTS:162556

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables U3 snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribosome biogenesis protein BMS1 homolog

Names: BMS1 homolog, ribosome assembly protein; BMS1-like, ribosome assembly protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194339.2 → NP_919320.1 ribosome biogenesis protein BMS1 homolog

Status: VALIDATED

Source sequence(s)

AC140466

Consensus CDS

CCDS20471.1

UniProtKB/TrEMBL

Q6PGF5, Q6ZQH0

Related

ENSMUSP00000032237.7, ENSMUST00000032237.8

Conserved Domains (4) summary

smart00785
Location:231 → 317

AARP2CN; AARP2CN (NUC121) domain

cd01882
Location:44 → 273

BMS1; Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes

COG5192
Location:17 → 1275

BMS1; GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]

pfam04950
Location:821 → 1108

RIBIOP_C; 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

118360342..118396772 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321497.3 → XP_017176986.1 ribosome biogenesis protein BMS1 homolog isoform X1

UniProtKB/TrEMBL

Q6ZQH0

Conserved Domains (1) summary

COG5192
Location:17 → 1301

BMS1; GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]