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    CYP710A1 cytochrome P450, family 710, subfamily A, polypeptide 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818013, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP710A1
    Official Full Name
    cytochrome P450, family 710, subfamily A, polypeptide 1
    Primary source
    TAIR:AT2G34500
    Locus tag
    AT2G34500
    See related
    Araport:AT2G34500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cytochrome P450; F13P17.35; family 710; polypeptide 1; subfamily A
    Summary
    Encodes a protein with C22-sterol desaturase activity. The enzyme was shown to catalyze in the presence of NADPH the conversion of &beta;-sitosterol to stigmasterol, but not that of 24-<i>epi</i>-campesterol to brassicasterol (unlike CYP710A2).
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    Genomic context

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    See CYP710A1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (14539373..14541617, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L18ae/LX family protein Neighboring gene cytochrome P450, family 710, subfamily A, polypeptide 2 Neighboring gene choice-of-anchor C domain protein, putative (Protein of unknown function, DUF642) Neighboring gene mitochondrial ribosomal protein S14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of CYP710A1 and CYP710A4 in transgenic Arabidopsis plants increases the level of stigmasterol at the expense of sitosterol. Arnqvist L, et al. Planta, 2008 Jan. PMID 17909855
    2. Arabidopsis histone H3 lysine 9 methyltransferases KYP/SUVH5/6 are involved in leaf development by interacting with AS1-AS2 to repress KNAT1 and KNAT2. Hung FY, et al. Commun Biol, 2023 Feb 24. PMID 36828846, Free PMC Article
    3. Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato. Morikawa T, et al. Plant Cell, 2006 Apr. PMID 16531502, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis histone H3 lysine 9 methyltransferases KYP/SUVH5/6 are involved in leaf development by interacting with AS1-AS2 to repress KNAT1 and KNAT2.
      Title: Arabidopsis histone H3 lysine 9 methyltransferases KYP/SUVH5/6 are involved in leaf development by interacting with AS1-AS2 to repress KNAT1 and KNAT2.
    2. The functions of CYP710A1 and CYP710A4 in stigmasterol synthesis are reported.
      Title: Overexpression of CYP710A1 and CYP710A4 in transgenic Arabidopsis plants increases the level of stigmasterol at the expense of sitosterol.
    3. In arabidopsis, cyp710A family may encode P450s of sterol C-22 desaturases in different organisms. [cyp710A1]
      Title: Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_129002.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables C-22 sterol desaturase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 710, subfamily A, polypeptide 1
    NP_180997.1
    • cytochrome P450, family 710, subfamily A, polypeptide 1 (CYP710A1); FUNCTIONS IN: C-22 sterol desaturase activity, oxygen binding; INVOLVED IN: oxidation reduction; LOCATED IN: endomembrane system; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: LP.04 four leaves visible, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, conserved site (InterPro:IPR017972), Cytochrome P450, E-class, group I (InterPro:IPR002401); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 710, subfamily A, polypeptide 2 (TAIR:AT2G34490.1); Has 25674 Blast hits to 25623 proteins in 1435 species: Archae - 46; Bacteria - 2777; Metazoa - 10394; Fungi - 4411; Plants - 7239; Viruses - 0; Other Eukaryotes - 807 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14539373..14541617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129002.3 → NP_180997.1  cytochrome P450, family 710, subfamily A, polypeptide 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180997.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64697
      UniProtKB/TrEMBL
      A0A178VRK5, A0A5S9X413
      Conserved Domains (1) summary
      cd11082
      Location:72 → 480
      CYP61_CYP710; C-22 sterol desaturase subfamily, such as fungal cytochrome P450 61 and plant cytochrome P450 710
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64697.1

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